Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation

MP Muller, T Jiang, C Sun, M Lihan, S Pant… - Chemical …, 2019 - ACS Publications
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

[書籍][B] Stochastic processes in cell biology

PC Bressloff - 2014 - Springer
One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Universal relation between instantaneous diffusivity and radius of gyration of proteins in aqueous solution

E Yamamoto, T Akimoto, A Mitsutake, R Metzler - Physical review letters, 2021 - APS
Protein conformational fluctuations are highly complex and exhibit long-term correlations.
Here, molecular dynamics simulations of small proteins demonstrate that these …

Lipid–protein interactions in plasma membrane organization and function

T Sych, KR Levental, E Sezgin - Annual review of biophysics, 2022 - annualreviews.org
Lipid–protein interactions in cells are involved in various biological processes, including
metabolism, trafficking, signaling, host–pathogen interactions, and transmembrane …

Heterogeneous anomalous transport in cellular and molecular biology

TA Waigh, N Korabel - Reports on Progress in Physics, 2023 - iopscience.iop.org
It is well established that a wide variety of phenomena in cellular and molecular biology
involve anomalous transport eg the statistics for the motility of cells and molecules are …

Non-Gaussian, non-ergodic, and non-Fickian diffusion of tracers in mucin hydrogels

AG Cherstvy, S Thapa, CE Wagner, R Metzler - Soft Matter, 2019 - pubs.rsc.org
Native mucus is polymer-based soft-matter material of paramount biological importance.
How non-Gaussian and non-ergodic is the diffusive spreading of pathogens in mucus? We …

Topology mediates transport of nanoparticles in macromolecular networks

X Dai, X Zhang, L Gao, Z Xu, LT Yan - Nature Communications, 2022 - nature.com
Diffusion transport of nanoparticles in confined environments of macromolecular networks is
common in diverse physical systems and regulates many biological responses …

Fractional Brownian motion with random diffusivity: emerging residual nonergodicity below the correlation time

W Wang, AG Cherstvy, AV Chechkin… - Journal of Physics A …, 2020 - iopscience.iop.org
Numerous examples for a priori unexpected non-Gaussian behaviour for normal and
anomalous diffusion have recently been reported in single-particle tracking experiments …

Transport of a graphene nanosheet sandwiched inside cell membranes

P Chen, H Yue, X Zhai, Z Huang, GH Ma, W Wei… - Science …, 2019 - science.org
The transport of nanoparticles at bio-nano interfaces is essential for many cellular responses
and biomedical applications. How two-dimensional nanomaterials, such as graphene and …