Managing osteoporosis in patients on long‐term bisphosphonate treatment: report of a task force of the American Society for Bone and Mineral Research
Bisphosphonates (BPs) are the most commonly used medications for osteoporosis. This
ASBMR report provides guidance on BP therapy duration with a risk‐benefit perspective …
ASBMR report provides guidance on BP therapy duration with a risk‐benefit perspective …
Bisphosphonates: the first 40 years
RGG Russell - Bone, 2011 - Elsevier
The first full publications on the biological effects of the diphosphonates, later renamed
bisphosphonates, appeared in 1969, so it is timely after 40 years to review the history of their …
bisphosphonates, appeared in 1969, so it is timely after 40 years to review the history of their …
Postmenopausal osteoporosis
R Eastell, TW O'Neill, LC Hofbauer… - Nature reviews Disease …, 2016 - nature.com
Osteoporosis is a metabolic bone disorder that is characterized by low bone mass and micro-
architectural deterioration of bone tissue. Fractures of the proximal femur, the vertebrae and …
architectural deterioration of bone tissue. Fractures of the proximal femur, the vertebrae and …
Pharmacology of bisphosphonates
S Cremers, MT Drake, FH Ebetino… - British journal of …, 2019 - Wiley Online Library
The biological effects of the bisphosphonates (BPs) as inhibitors of calcification and bone
resorption were first described in the late 1960s. In the 50 years that have elapsed since …
resorption were first described in the late 1960s. In the 50 years that have elapsed since …
Bone-targeted nanoparticle drug delivery system: an emerging strategy for bone-related disease
Targeted delivery by either systemic or local targeting of therapeutics to the bone is an
attractive treatment for various bone metabolism diseases such as osteoporosis …
attractive treatment for various bone metabolism diseases such as osteoporosis …
Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression
The Western pattern diet is rich not only in fat and calories but also in phosphate. The
negative effects of excessive fat and calorie intake on health are widely known, but the …
negative effects of excessive fat and calorie intake on health are widely known, but the …
Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use
Abstract The bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2, BPs) were first shown to
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …
The role of the phosphorus atom in drug design
Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …
Benefits and risks of bisphosphonate therapy for osteoporosis
Context: There has been considerable concern recently in the scientific and lay media
regarding the benefits vs. the risks of bisphosphonates for the treatment of osteoporosis …
regarding the benefits vs. the risks of bisphosphonates for the treatment of osteoporosis …
Bisphosphonates—much more than only drugs for bone diseases
A Kuźnik, A Październiok-Holewa, P Jewula… - European journal of …, 2020 - Elsevier
Abstract α, α-Bisphosphonates (BPs) are well established in the treatment of bone diseases
such as osteoporosis and Paget's disease. Their successful application originates from their …
such as osteoporosis and Paget's disease. Their successful application originates from their …