The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

Therapeutic peptides are a major class of pharmaceutical drugs owing to their target‐
binding specificity as well as their versatility in inhibiting aberrant protein‐protein …

Amyloid-β (Aβ) aggregation plays a key role in the pathogenesis of Alzheimer's disease
(AD). Along with this, the presence of redox-active metals like Cu2+ further enhances Aβ …

The aggregation of proteins into ordered fibrillar structures called amyloids, and their
disintegration represent major unsolved problems that limit the therapeutic applications of …

According to clinical studies, the development of Alzheimer's disease (AD) is linked to the
abnormal aggregation of amyloid-β (Aβ) peptides into toxic soluble oligomers, protofibrils as …

Multi-epitope vaccines strategically tackle rapidly mutating viruses by targeting diverse
epitopes from different proteins, providing a comprehensive and adaptable immune …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease mainly characterized
by extracellular accumulation of amyloid-β (Aβ) peptide. Previous studies reported …

The etiology of Parkinson's disease (PD) is mainly linked to the α-synuclein (α-Syn)
fibrillogenesis. Hydroxytyrosol (HT), also known as 3, 4-dihydroxyphenylethanol, is a …

The aberrant deposition of α-synuclein (α-Syn) protein into the intracellular neuronal
aggregates termed Lewy bodies and Lewy neurites characterizes the devastating …

The aberrant misfolding and self-aggregation of human islet amyloid polypeptide (hIAPP or
amylin) into cytotoxic aggregates are implicated in the pathogenesis of type 2 diabetes …