Tumour formation involves random mutagenic events and positive evolutionary selection
acting on a subset of such events, referred to as driver mutations. A decade of careful …

Although the study of leukemogenesis has traditionally focused on protein-coding genes,
the role of enhancer dysregulation is becoming increasingly recognized. The advent of high …

Transposable elements or transposons are major players in genetic variability and genome
evolution. Aberrant activation of long interspersed element-1 (LINE-1 or L1) …

Metabolic requirements vary during development, and our understanding of how metabolic
activity influences cell specialization is incomplete. Here, we describe a switch from …

Relapse of acute myeloid leukemia (AML) is highly aggressive and often treatment
refractory. We analyzed previously published AML relapse cohorts and found that 40% of …

Background The high mutation rate throughout the entire melanoma genome presents a
major challenge in stratifying true driver events from the background mutations. Numerous …

Large-scale cancer genome sequencing has enabled the catalogs of somatic mutations;
however, the mutational impact on intrinsically disordered protein regions (IDRs) has not …

Somatic single nucleotide variants (SNVs) in cancer genome affect gene expression through
various mechanisms depending on their genomic location. While somatic SNVs near …

Mutations in IDH genes occur frequently in acute myeloid leukemia (AML) and other human
cancers to generate the oncometabolite R-2HG. Allosteric inhibition of mutant IDH …

Many cancers are organized as cellular hierarchies sustained by cancer stem cells (CSC),
whose eradication is crucial for achieving long-term remission. Difficulties to isolate and …