The JAK-STAT pathway at 30: Much learned, much more to do
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
JAK‐STAT core cancer pathway: an integrative cancer interactome analysis
Through a comprehensive review and in silico analysis of reported data on STAT‐linked
diseases, we analysed the communication pathways and interactome of the seven STATs in …
diseases, we analysed the communication pathways and interactome of the seven STATs in …
STAT5b: A master regulator of key biological pathways
MR Smith, LRF Satter… - Frontiers in immunology, 2023 - frontiersin.org
The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in
immune regulation and homeostasis and play a crucial role in the development and function …
immune regulation and homeostasis and play a crucial role in the development and function …
STAT3 and STAT5 activation in solid cancers
The Signal Transducer and Activator of Transcription (STAT) 3 and 5 proteins are activated
by many cytokine receptors to regulate specific gene expression and mitochondrial …
by many cytokine receptors to regulate specific gene expression and mitochondrial …
Direct targeting options for STAT3 and STAT5 in cancer
Signal transducer and activator of transcription (STAT) 3 and STAT5 are important
transcription factors that are able to mediate or even drive cancer progression through …
transcription factors that are able to mediate or even drive cancer progression through …
Molecular dynamics simulations and diversity selection by extended continuous similarity indices
Molecular dynamics (MD) is a core methodology of molecular modeling and computational
design for the study of the dynamics and temporal evolution of molecular systems. MD …
design for the study of the dynamics and temporal evolution of molecular systems. MD …
Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R–STAT5B-driven neoplasms
N Sumaria, GJ Fiala, D Inácio, M Curado-Avelar… - Nature …, 2024 - nature.com
The contribution of γδ T cells to immune responses is associated with rapid secretion of
interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T …
interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T …
Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia
CD4+ T-cell large granular lymphocyte leukemia (T-LGLL) is a rare subtype of T-LGLL with
unknown etiology. In this study, we molecularly characterized a cohort of patients (n= 35) by …
unknown etiology. In this study, we molecularly characterized a cohort of patients (n= 35) by …
Suppressing STAT5 signaling affects osteosarcoma growth and stemness
D Subramaniam, P Angulo, S Ponnurangam… - Cell death & …, 2020 - nature.com
Osteosarcoma (OS) is the most common primary bone tumor that primarily affects children
and adolescents. Studies suggested that dysregulation JAK/STAT signaling promotes the …
and adolescents. Studies suggested that dysregulation JAK/STAT signaling promotes the …
Pharmacological inhibition of oncogenic STAT3 and STAT5 signaling in hematopoietic cancers
M Brachet-Botineau, M Polomski, HA Neubauer… - Cancers, 2020 - mdpi.com
Signal Transducer and Activator of Transcription (STAT) 3 and 5 are important effectors of
cellular transformation, and aberrant STAT3 and STAT5 signaling have been demonstrated …
cellular transformation, and aberrant STAT3 and STAT5 signaling have been demonstrated …