Stereoselective synthesis has been emerging as a resourceful tool because it enables the
obtaining of compounds with biological interest and high enantiomeric purity. Flavonoids are …

Chalcones are an interesting class of compounds endowed with a plethora of biological
activities beneficial to human health. These chemotypes have continued to attract increased …

Benzodiazepines (BZDs) represent a class of privilege scaffold in the modern era of
medicinal chemistry as CNS active agents and BZD based drugs are used to treat different …

Objective: Chalcone-3 has been shown to be cytotoxic and selective against luminal
subtype breast cancer cell lines, which are suspected to occur through the mechanism of …

The synthesis of N-phenylpyrazolines 1-5 was performed by the cyclocondensation of
phenylhydrazine and appropriate chalcones that have been synthesized from our previous …

Abstract A simple fluorescent chemosensor 5-(4-methylphenyl)-3-(5-methylfuran-2-yl)-1-
phenyl-4, 5-dihydro-1 H-pyrazole (PY) has been synthesized for the detection of Cd2+ ion …

Epidermal growth factor receptor (EGFR) is found to be overexpressed in cancer cells as it
controls angiogenesis, cell signaling, and proliferation mechanisms. Therefore, EGFR has …

Malaria remains an endemic disease in tropical regions, urgently needed the search for
effective antimalarial agents due to resistance against existing drugs. This study investigated …

A quantitative structure-activity relationship (QSAR) analysis of serial chalcone derivatives
as antimalarial agents against Plasmodium falciparum strain 3D7 (Pf3D7) was conducted, it …

Purpose: To synthesize chloro-pyrazolines (A–D), determine their antimalarial activity
against Plasmodium falciparum strain 3D7 in vitro, and understand the interaction between …