Humic acids: Structural properties and multiple functionalities for novel technological developments

BAG de Melo, FL Motta, MHA Santana - Materials Science and …, 2016 - Elsevier
Humic acids (HAs) are macromolecules that comprise humic substances (HS), which are
organic matter distributed in terrestrial soil, natural water, and sediment. HAs differ from the …

The current role of cannabis and cannabinoids in health: A comprehensive review of their therapeutic potential

MP Coelho, P Duarte, M Calado, AJ Almeida, CP Reis… - Life Sciences, 2023 - Elsevier
There has been an increased interest of the scientific community in cannabis and its
constituents for therapeutic purposes. Although it is believed that cannabinoids can be …

[HTML][HTML] Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer

AM Mahmoud, M Kostrzewa, V Marolda… - Pharmacological …, 2023 - Elsevier
In spite of the huge advancements in both diagnosis and interventions, hormone refractory
prostate cancer (HRPC) remains a major hurdle in prostate cancer (PCa). Metabolic …

Cannabis and its constituents for cancer: History, biogenesis, chemistry and pharmacological activities

S Lal, A Shekher, AS Narula, H Abrahamse… - Pharmacological …, 2021 - Elsevier
Cannabis has long been used for healing and recreation in several regions of the world.
Over 400 bioactive constituents, including more than 100 phytocannabinoids, have been …

Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update

P Morales, L Hernandez-Folgado, P Goya… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Modulation of the CB2 receptor is an interesting approach for pain and
inflammation, arthritis, addictions, neuroprotection, and cancer, among other possible …

[HTML][HTML] Cannabinoids and PPAR ligands: the future in treatment of polycystic ovary syndrome women with obesity and reduced fertility

P Przybycień, D Gąsior-Perczak, W Placha - Cells, 2022 - mdpi.com
Cannabinoids (CBs) are used to treat chronic pain, chemotherapy-induced nausea and
vomiting, and multiple sclerosis spasticity. Recently, the medicinal use of CBs has attracted …

Relevance of peroxisome proliferator activated receptors in multitarget paradigm associated with the endocannabinoid system

A Lago-Fernandez, S Zarzo-Arias, N Jagerovic… - International journal of …, 2021 - mdpi.com
Cannabinoids have shown to exert their therapeutic actions through a variety of targets.
These include not only the canonical cannabinoid receptors CB1R and CB2R but also …

[HTML][HTML] The pathophysiology and the therapeutic potential of cannabinoids in prostate cancer

K Singh, N Nassar, A Bachari, E Schanknecht… - Cancers, 2021 - mdpi.com
Simple Summary Prostate cancer, after lung cancer, is the leading cause of death among
men. The incidence rate of prostate cancer varies worldwide between regions and …

Novel approaches and current challenges with targeting the endocannabinoid system

P Morales, N Jagerovic - Expert opinion on drug discovery, 2020 - Taylor & Francis
Introduction The pathophysiological relevance of the endocannabinoid system has been
widely demonstrated in a variety of diseases including cancer, neurological disorders, and …

Cannabinoid quinones—A review and novel observations

NM Kogan, M Peters, R Mechoulam - Molecules, 2021 - mdpi.com
A cannabinoid anticancer para-quinone, HU-331, which was synthesized by our group five
decades ago, was shown to have very high efficacy against human cancer cell lines in-vitro …