Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics
Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …
mediated transcription: protein-coding transcription units and non-coding RNA transcription …
Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII
Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …
and steady expression of some proteins as well as the rapidly changing production of other …
3′-end processing of eukaryotic mRNA: machinery, regulation, and impact on gene expression
V Boreikaitė, LA Passmore - Annual review of biochemistry, 2023 - annualreviews.org
Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …
transcript. This process is mediated by a number of protein factors that cleave the pre …
Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation
Cleavage and polyadenylation (CPA) is responsible for 3′ end processing of eukaryotic
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …
Widespread remodeling of the m6A RNA-modification landscape by a viral regulator of RNA processing and export
N 6-methyladenosine (m6A) is the most abundant internal messenger RNA (mRNA)
modification, contributing to the processing, stability, and function of methylated RNAs …
modification, contributing to the processing, stability, and function of methylated RNAs …
Translation—a tug of war during viral infection
Viral reproduction is contingent on viral protein synthesis that relies on the host ribosomes.
As such, viruses have evolved remarkable strategies to hijack the host translational …
As such, viruses have evolved remarkable strategies to hijack the host translational …
HSV-1 DNA replication—coordinated regulation by viral and cellular factors
JE Packard, JA Dembowski - Viruses, 2021 - mdpi.com
DNA replication is an integral step in the herpes simplex virus type 1 (HSV-1) life cycle that
is coordinated with the cellular DNA damage response, repair and recombination of the viral …
is coordinated with the cellular DNA damage response, repair and recombination of the viral …
Hyperosmotic stress alters the RNA polymerase II interactome and induces readthrough transcription despite widespread transcriptional repression
Stress-induced readthrough transcription results in the synthesis of downstream-of-gene
(DoG)-containing transcripts. The mechanisms underlying DoG formation during cellular …
(DoG)-containing transcripts. The mechanisms underlying DoG formation during cellular …
SRSF3 and SRSF7 modulate 3′ UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels
Background Alternative polyadenylation (APA) refers to the regulated selection of
polyadenylation sites (PASs) in transcripts, which determines the length of their 3 …
polyadenylation sites (PASs) in transcripts, which determines the length of their 3 …
mRNA 3'UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus
Abstract Changes of mRNA 3'UTRs by alternative polyadenylation (APA) have been
associated to numerous pathologies, but the mechanisms and consequences often remain …
associated to numerous pathologies, but the mechanisms and consequences often remain …