Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …

The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …

Clustered regularly interspaced short palindromic repeat (CRISPR)-based genome editing
(GED) technologies have unlocked exciting possibilities for understanding genes and …

Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-
propagating conformations, leading to rapid-onset dementia and death. However …

Major progress has been made with genomic and genetic studies in aquaculture in the last
decade. However, research on epigenetic regulation of aquaculture traits is still at an early …

Childhood trauma (CT) can have persistent effects on the brain and is one of the major risk
factors for neuropsychiatric diseases in adulthood. Recent advances in the field of …

The advancement in epigenetics research over the past several decades has led to the
potential application of epigenome-editing technologies for the treatment of various …

Abstract The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/Cas9
system, a groundbreaking innovation in genetic engineering, has revolutionized our …

Abstract Chimeric Antigen Receptor (CAR)-T-cell therapy has revolutionized cancer immune
therapy. However, challenges remain including increasing efficacy, reducing adverse events …

Highlights•Engineering cells as living therapeutics offers enhanced disease
targeting.•Delivering mRNA in vivo offers a platform to advance in vivo cellular …