Gut microbiota in colorectal cancer development and therapy

CC Wong, J Yu - Nature Reviews Clinical Oncology, 2023 - nature.com
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

Targeting the gut and tumor microbiota in cancer

EM Park, M Chelvanambi, N Bhutiani, G Kroemer… - Nature medicine, 2022 - nature.com
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
sha** cancer immunosurveillance and response to immunotherapy. Our understanding of …

Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies

T Tian, Z Wang, J Zhang - Oxidative medicine and cellular …, 2017 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has
risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an …

[HTML][HTML] Gut microbiota imbalance and colorectal cancer

J Gagnière, J Raisch, J Veziant, N Barnich… - World journal of …, 2016 - ncbi.nlm.nih.gov
The gut microbiota acts as a real organ. The symbiotic interactions between resident micro-
organisms and the digestive tract highly contribute to maintain the gut homeostasis …

[HTML][HTML] Gut microbiome in gastrointestinal cancer: a friend or foe?

Y Liu, Y Baba, T Ishimoto, X Gu, J Zhang… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
The impact of the gut microbiome on host health is becoming increasingly recognized. To
date, there is growing evidence that the complex characteristics of the microbial community …

Gut microbiota in colorectal cancer: biological role and therapeutic opportunities

H Pandey, DWT Tang, SH Wong, D Lal - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the second-leading cause of cancer-related
deaths worldwide. In this review article, we examine the role of gut microbiota in the …

Potential effects of gut microbiota on host cancers: focus on immunity, DNA damage, cellular pathways, and anticancer therapy

J Sun, F Chen, G Wu - The ISME Journal, 2023 - academic.oup.com
The symbiotic bacteria that live in the human gut and the metabolites they produce have
long influenced local and systemic physiological and pathological processes of the host …

Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development

J Allen, CL Sears - Genome medicine, 2019 - Springer
In recent years, the number of studies investigating the impact of the gut microbiome in
colorectal cancer (CRC) has risen sharply. As a result, we now know that various microbes …

Gut microbiota and colorectal cancer

R Gao, Z Gao, L Huang, H Qin - European Journal of Clinical Microbiology …, 2017 - Springer
The gut microbiota is considered as a forgotten organ in human health and disease. It
maintains gut homeostasis by various complex mechanisms. However, disruption of the gut …

Colon carcinogenesis: the interplay between diet and gut microbiota

YL Loke, MT Chew, YF Ngeow, WWD Lim… - Frontiers in cellular and …, 2020 - frontiersin.org
Colorectal cancer (CRC) incidence increases yearly, and is three to four times higher in
developed countries compared to develo** countries. The well-known risk factors have …