[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

Preeclampsia: Pathophysiology and management

R Nirupama, S Divyashree, P Janhavi… - Journal of gynecology …, 2021 - Elsevier
Preeclampsia is a pregnancy-related multisystem disorder, frequently encountered
pregnancy-related medical complications next to gestational diabetes mellitus. It is the onset …

[HTML][HTML] The International Federation of Gynecology and Obstetrics (FIGO) initiative on preeclampsia (PE): a pragmatic guide for first trimester screening and …

LC Poon, A Shennan, JA Hyett, A Kapur… - … of gynaecology and …, 2019 - ncbi.nlm.nih.gov
Preeclampsia (PE) is a multisystem disorder that typically affects 2%− 5% of pregnant
women and is one of the leading causes of maternal and perinatal morbidity and mortality …

The “Great Obstetrical Syndromes” are associated with disorders of deep placentation

I Brosens, R Pijnenborg, L Vercruysse… - American journal of …, 2011 - Elsevier
Defective deep placentation has been associated with a spectrum of complications of
pregnancy including preeclampsia, intrauterine growth restriction, preterm labor, preterm …

Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease

CE Powe, RJ Levine, SA Karumanchi - Circulation, 2011 - Am Heart Assoc
Preeclampsia is a clinical syndrome defined as the new onset of hypertension and
proteinuria during the second half of pregnancy. 1 It afflicts 3% to 5% of pregnancies and is …

Early prediction of preeclampsia

LC Poon, KH Nicolaides - Obstetrics and gynecology …, 2014 - Wiley Online Library
Effective screening for the development of early onset preeclampsia (PE) can be provided in
the first‐trimester of pregnancy. Screening by a combination of maternal risk factors, uterine …

Angiogenic factors and preeclampsia

SE Maynard, SA Karumanchi - Seminars in nephrology, 2011 - Elsevier
Preeclampsia, a hypertensive disorder peculiar to pregnancy, is a systemic syndrome that
appears to originate in the placenta and is characterized by widespread maternal …

Redefining preeclampsia using placenta-derived biomarkers

AC Staff, SJ Benton, P von Dadelszen, JM Roberts… - …, 2013 - Am Heart Assoc
Compared with the nonpregnant state, normal pregnancy is characterized by a low-grade
systemic inflammatory response, which is further enhanced in preeclampsia. 17 It is …

Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia

L Ji, J Brkić, M Liu, G Fu, C Peng, YL Wang - Molecular aspects of medicine, 2013 - Elsevier
The placenta is a transient organ that forms during pregnancy to support the growth and
development of the fetus. During human placental development, trophoblast cells …

Removal of soluble fms-like tyrosine kinase-1 by dextran sulfate apheresis in preeclampsia

R Thadhani, H Hagmann… - Journal of the …, 2016 - journals.lww.com
Preeclampsia is a devastating complication of pregnancy. Soluble Fms-like tyrosine kinase-
1 (sFlt-1) is an antiangiogenic protein believed to mediate the signs and symptoms of …