Metastatic dissemination occurs very early in the malignant progression of a cancer but the
clinical manifestation of metastases often takes years. In recent decades, 5-year survival of …

Surgical resection is an important avenue for cancer treatment, which, in most cases, can
effectively alleviate the patient symptoms. However, accumulating evidence has …

Background Bone metastasis is the leading cause of death in patients with prostate cancer
(PCa) and currently has no effective treatment. Disseminated tumor cells in bone marrow …

Cancer recurrence and metastasis, following successful treatment, constitutes a critical
threat in clinical oncology and are the leading causes of death amongst cancer patients …

The poor outcomes in esophageal adenocarcinoma (EAC) prompted us to interrogate the
pattern and timing of metastatic spread. Whole-genome sequencing and phylogenetic …

Activating invasion and metastasis are one of the primary hallmarks of cancer, the latter
representing the leading cause of death in cancer patients. Whilst many advances in this …

Simple Summary Esophageal adenocarcinoma (EAC) is one of the two main subtypes of
esophageal cancer. EAC is a highly lethal disease with rising incidence in Western …

Detection of disseminated tumor cells (DTCs) in bone marrow is an established negative
prognostic factor. We isolated small pools of (~ 20) EPCAM-positive DTCs from early breast …

Malignant epithelial tumors of the upper digestive tract are a major cause of cancer-related
death worldwide. The most common of these cancers are head and neck squamous cell …

Considering the limited information on the biology and molecular characteristics of
disseminated tumor cells (DTCs) in head and neck squamous cell carcinoma (HNSCC), we …