Genetic and environmental risk factors for rheumatoid arthritis

KD Deane, MK Demoruelle, LB Kelmenson… - Best practice & research …, 2017 - Elsevier
Multiple genetic and environmental factors have been associated with an increased risk for
rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female …

The case for periodontitis in the pathogenesis of rheumatoid arthritis

J Potempa, P Mydel, J Koziel - Nature Reviews Rheumatology, 2017 - nature.com
Rheumatoid arthritis (RA), an autoimmune disease that affects∼ 1% of the human
population, is driven by autoantibodies that target modified self-epitopes, whereas∼ 11% of …

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

VM Holers, MK Demoruelle, KA Kuhn… - Nature Reviews …, 2018 - nature.com
Individuals at high risk of develo** seropositive rheumatoid arthritis (RA) can be identified
for translational research and disease prevention studies through the presence of highly …

Etiology and risk factors for rheumatoid arthritis: a state-of-the-art review

VC Romão, JE Fonseca - Frontiers in medicine, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It is
associated with significant burden at the patient and societal level. Extensive efforts have …

No genetic causal association between periodontitis and arthritis: A bidirectional two-sample mendelian randomization analysis

KJ Yin, JX Huang, P Wang, XK Yang, SS Tao… - Frontiers in …, 2022 - frontiersin.org
Objectives Periodontitis (PD) has been linked to arthritis in previous epidemiological
observational studies; however, the results are inconclusive. It remains unclear whether the …

Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?

J González‐Febles, M Sanz - Periodontology 2000, 2021 - Wiley Online Library
Rheumatoid arthritis and periodontitis are chronic inflammatory diseases defined
respectively by the destruction of the articular cartilage and tooth‐supporting periodontal …

Periodontitis and Porphyromonas gingivalis in Patients With Rheumatoid Arthritis

TR Mikuls, JB Payne, F Yu, GM Thiele… - Arthritis & …, 2014 - Wiley Online Library
Objective To examine the degree to which shared risk factors explain the relationship of
periodontitis (PD) to rheumatoid arthritis (RA) and to determine the associations of PD and …

Citrullination and autoimmunity

G Valesini, MC Gerardi, C Iannuccelli, VA Pacucci… - Mosaic of …, 2019 - Elsevier
Autoimmune diseases are characterized by the body's own immune system attack to the self-
tissues, a condition enabled, in predisposed subjects, by the reduction of self-tolerance. A …

Periodontal disease and rheumatoid arthritis: a systematic review

S Kaur, S White, PM Bartold - Journal of dental research, 2013 - journals.sagepub.com
This systematic review considers the evidence available for a relationship between
periodontal disease and rheumatoid arthritis. MEDLINE/PubMed, CINAHL, DOSS, Embase …

Oral dysbiosis and autoimmunity: from local periodontal responses to an imbalanced systemic immunity. A review

LJ Suárez, H Garzón, S Arboleda… - Frontiers in …, 2020 - frontiersin.org
The current paradigm of onset and progression of periodontitis includes oral dysbiosis
directed by inflammophilic bacteria, leading to altered resolution of inflammation and lack of …