Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

Importance Increasing evidence suggests an important role of liver function in the
pathophysiology of Alzheimer disease (AD). The liver is a major metabolic hub; therefore …

Alzheimer's disease is one of the most common causes of mental deterioration in elderly
people, accounting for around 50%-60% of the overall cases of dementia among persons …

This study investigated cerebral glucose metabolism in very early Alzheimer's disease,
before a clinical diagnosis of probable Alzheimer's disease is possible, using [18F] …

GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly
expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a …

Neither normal brain function nor the pathological processes involved in neurological
diseases can be adequately understood without knowledge of the release, uptake and …

Abstract l-Glutamate is the most abundant of a group of endogenous amino acids in the
mammalian central nervous system which presumably function as excitatory …

Recent evidence suggests that Alzheimer's disease (AD) and depression share common
mechanisms of pathogenesis. In particular, deregulation of glutamate-mediated excitatory …

Alzheimer's disease (AD), the most common cause of dementia, is a progressive
neurodegenerative disease. The number of AD cases has been rapidly growing worldwide …