In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human
cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 …

The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …

P53 is a transcription factor highly inducible by many stress signals such as DNA damage,
oncogene activation, and nutrient deprivation. Cell-cycle arrest and apoptosis are the most …

While the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated …

Disease is often the result of an aberrant or inadequate response to physiologic and
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …

Thirty years ago p53 was discovered as a cellular partner of simian virus 40 large T-antigen,
the oncoprotein of this tumour virus. The first decade of p53 research saw the cloning of p53 …

With the advent of next generation sequencing techniques a previously unknown world of
non-coding RNA molecules have been discovered. Non-coding RNA transcripts likely …

Following the discovery of nucleic acids by Friedrich Miescher in 1868, DNA and RNA were
recognized as the genetic code containing the necessary information for proper cell …