Severe covid-19 pneumonia: pathogenesis and clinical management

AH Attaway, RG Scheraga, A Bhimraj, M Biehl… - bmj, 2021‏ - bmj.com
Severe covid-19 pneumonia has posed critical challenges for the research and medical
communities. Older age, male sex, and comorbidities increase the risk for severe disease …

The glycosylation in SARS-CoV-2 and its receptor ACE2

Y Gong, S Qin, L Dai, Z Tian - Signal Transduction and Targeted …, 2021‏ - nature.com
Abstract Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

C Junqueira, Â Crespo, S Ranjbar, LB De Lacerda… - Nature, 2022‏ - nature.com
SARS-CoV-2 can cause acute respiratory distress and death in some patients. Although
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …

Structural insights into SARS-CoV-2 proteins

R Arya, S Kumari, B Pandey, H Mistry, SC Bihani… - Journal of molecular …, 2021‏ - Elsevier
The unprecedented scale of the ongoing COVID-19 pandemic has catalyzed an intense
effort of the global scientific community to unravel different aspects of the disease in a short …

Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

YW Zhou, Y **e, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021‏ - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …

Characterization of the SARS‐CoV‐2 E protein: sequence, structure, viroporin, and inhibitors

Y Cao, R Yang, I Lee, W Zhang, J Sun, W Wang… - Protein …, 2021‏ - Wiley Online Library
The COVID‐19 epidemic is one of the most influential epidemics in history. Understanding
the impact of coronaviruses (CoVs) on host cells is very important for disease treatment. The …

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

C Sun, C **e, GL Bu, LY Zhong, MS Zeng - Signal Transduction and …, 2022‏ - nature.com
The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …

SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release

C Junqueira, Â Crespo, S Ranjbar… - Research …, 2021‏ - pmc.ncbi.nlm.nih.gov
SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and
death in a minority of patients. Although severe COVID-19 disease is linked to exuberant …

Cholesterol-rich lipid rafts as platforms for SARS-CoV-2 entry

SN Palacios-Rápalo, LA De Jesus-Gonzalez… - Frontiers in …, 2021‏ - frontiersin.org
Since its appearance, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2),
the causal agent of Coronavirus Disease 2019 (COVID-19), represents a global problem for …

The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation

Z Li, P Hao, Z Zhao, W Gao, C Huan, L Li… - Signal transduction and …, 2023‏ - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a severe global health crisis; …