Zoonotic spillover: Understanding basic aspects for better prevention

JH Ellwanger, JAB Chies - Genetics and Molecular Biology, 2021 - SciELO Brasil
The transmission of pathogens from wild animals to humans is called “zoonotic spillover”.
Most human infectious diseases (60-75%) are derived from pathogens that originally …

[HTML][HTML] Beyond HIV infection: neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases

JH Ellwanger, B Kulmann-Leal, V de Lima Kaminski… - Virus research, 2020 - Elsevier
The interactions between chemokine receptors and their ligands may affect susceptibility to
infectious diseases as well as their clinical manifestations. These interactions mediate both …

MicroRNA-related polymorphisms in infectious diseases—tiny changes with a huge impact on viral infections and potential clinical applications

JH Ellwanger, FMB Zambra, RL Guimarães… - Frontiers in …, 2018 - frontiersin.org
MicroRNAs (miRNAs) are single-stranded sequences of non-coding RNA with
approximately 22 nucleotides that act posttranscriptionally on gene expression. miRNAs are …

Association of toll-like receptors single nucleotide polymorphisms with HBV and HCV infection: research status

Y Xu, W Xue, H Gao, J Cui, L Zhao, C You - PeerJ, 2022 - peerj.com
Background Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections have become
increasingly severe worldwide and are a threat to public health. There have been a number …

Host immunogenetics in tick-borne encephalitis virus infection—The CCR5 crossroad

JH Ellwanger, JAB Chies - Ticks and tick-borne diseases, 2019 - Elsevier
The human Tick-borne encephalitis virus (TBEV) infection is a complex event encompassing
factors derived from the virus itself, the vectors, the final host, and the environment as well …

Insights into the Correlation between Toll‐Like Receptor 2 Polymorphism and HBV‐Related Disease Progression and Occurrence of Hepatocellular Carcinoma: A …

NS Elabd, ML Helal, M Elkhayat… - Canadian Journal of …, 2024 - Wiley Online Library
Background and Aim. Hepatitis B virus (HBV) infection causes a variety of clinical
manifestations, including liver cirrhosis and hepatocellular carcinoma (HCC). Toll‐like …

CCR5Δ32 in HCV infection, HCV/HIV co-infection, and HCV-related diseases

JH Ellwanger, BK Leal, JM Valverde-Villegas… - Infection, Genetics and …, 2018 - Elsevier
Although a potential involvement of the CCR5Δ32 variant has already been suggested in
relation to susceptibility to hepatitis C virus (HCV) infection, data from the literature is still …

HLA‐G 3′UTR haplotype analyses in HCV infection and HCV‐derived cirrhosis, hepatocellular carcinoma and fibrosis

JD Oliveira Correa, FMB Zambra… - International Journal …, 2023 - Wiley Online Library
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease. Chronic HCV
infection is also an important cause of hepatic fibrosis, cirrhosis and hepatocellular …

IP-10 interferes with the antiviral response of direct-acting antiviral agents for hepatitis C virus infection

Y Wang, Y Hu, X Zhang, Y Luo, L Ma, J Lu… - Frontiers in Public …, 2022 - frontiersin.org
Background Increased interferon (IFN)-gamma inducible protein-10 (IP-10) level has been
shown to be associated with sustained virologic responses (SVRs) to pegylated interferon …

Immunogenetics in the diagnosis of clinical disorders

D Ash, T Roy - Immunogenetics: A Molecular and Clinical Overview, 2022 - Elsevier
The human major histocompatibility complex (MHC) spans around 4 Mbp on the short arm of
chromosome 6 and contains more than 200 highly packed genes, which show a high …