PPAR beta/delta and the hallmarks of cancer

N Wagner, KD Wagner - Cells, 2020 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone
receptor family. Three different isoforms, PPAR alpha, PPAR beta/delta and PPAR gamma …

[HTML][HTML] Peroxisome proliferator-activated receptors (PPARs) are potential drug targets for cancer therapy

Q Gou, X Gong, J **, J Shi, Y Hou - Oncotarget, 2017 - ncbi.nlm.nih.gov
Peroxisome-proliferator-activated receptors (PPARs) are nuclear hormone receptors
including PPARα, PPARδ and PPARγ, which play an important role in regulating cancer cell …

Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma

W Ou, RS Mulik, A Anwar, JG McDonald, X He… - Free Radical Biology …, 2017 - Elsevier
Low-density lipoprotein nanoparticles reconstituted with the natural omega-3 fatty acid,
docosahexaenoic acid (LDL-DHA), have been reported to selectively kill hepatoma cells …

Role of 4-hydroxynonenal-protein adducts in human diseases

G Barrera, S Pizzimenti, ES Ciamporcero… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: Oxidative stress provokes the peroxidation of polyunsaturated fatty acids in
cellular membranes, leading to the formation of aldheydes that, due to their high chemical …

PPARβ/δ: linking metabolism to regeneration

A Magadum, FB Engel - International Journal of Molecular Sciences, 2018 - mdpi.com
In contrast to the general belief that regeneration is a rare event, mainly occurring in simple
organisms, the ability of regeneration is widely distributed in the animal kingdom. Yet, the …

Peroxisome proliferator-activated receptors and the hallmarks of cancer

N Wagner, KD Wagner - Cells, 2022 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors
upon the binding of physiological or pharmacological ligands and heterodimerization with …

Establishing the Role of PPARβ/δ in Carcinogenesis

JM Peters, FJ Gonzalez, R Müller - Trends in Endocrinology & Metabolism, 2015 - cell.com
The role of the nuclear hormone receptor peroxisome proliferator-activated receptor β/δ
(PPARβ/δ) in carcinogenesis is controversial because conflicting studies indicate that it both …

The role of peroxisome proliferator-activated receptors in the tumor microenvironment, tumor cell metabolism, and anticancer therapy

J Sun, L Yu, X Qu, T Huang - Frontiers in Pharmacology, 2023 - frontiersin.org
Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for over
3 decades and consist of three isotypes, including PPARα, γ, and β/δ, that were originally …

PPAR-delta promotes survival of breast cancer cells in harsh metabolic conditions

X Wang, G Wang, Y Shi, L Sun, R Gorczynski, YJ Li… - Oncogenesis, 2016 - nature.com
Expression of the nuclear receptor peroxisome proliferator activated receptor delta (PPARδ)
in breast cancer cells is negatively associated with patient survival, but the underlying …

The functional role of voltage-gated sodium channel Nav1. 5 in metastatic breast cancer

Q Luo, T Wu, W Wu, G Chen, X Luo, L Jiang… - Frontiers in …, 2020 - frontiersin.org
Voltage-gated sodium channels (VGSCs), which are abnormally expressed in various types
of cancers such as breast cancer, prostate cancer, lung cancer, and cervical cancer, are …