The recognition that gene expression can be substantially stochastic poses the question of
how cells respond to dynamic environments using biochemistry that itself fluctuates. The …

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary
gonadotropes to control reproduction. These are G q-coupled receptors that mediate acute …

Cells must sense extracellular signals and transfer the information contained about their
environment reliably to make appropriate decisions. To perform these tasks, cells use signal …

The invention of the Kalman filter is a crowning achievement of filtering theory—one that has
revolutionized technology in countless ways. By dealing effectively with noise, the Kalman …

Simulation of biomolecular networks is now indispensable for studying biological systems,
from small reaction networks to large ensembles of cells. Here we present a novel approach …

Cell-to-cell heterogeneity is driven by stochasticity in intracellular reactions and the
population dynamics. While these sources are usually studied separately, we develop an …

The dynamic signal encoding paradigm suggests that information flows from the
extracellular environment into specific signaling patterns (encoding) that are then read by …

The dynamics of stochastic reaction networks within cells are inevitably modulated by factors
considered extrinsic to the network such as, for instance, the fluctuations in ribosome copy …

Background All living systems acquire information about their environment. At the cellular
level, they do so through signaling pathways. Such pathways rely on reversible binding …

Cell signaling pathways are noisy communication channels, and statistical measures
derived from information theory can be used to quantify the information they transfer. Here …