Transcranial magnetic stimulation (TMS) is a powerful tool to probe in vivo brain circuits, as it
allows to assess several cortical properties such as excitability, plasticity and connectivity in …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

Summary α-Synucleinopathies are neurodegenerative diseases characterised by the
abnormal accumulation of α-synuclein aggregates in neurons, nerve fibres or glial cells …

Purpose Patients suffering from cardiovascular autonomic failure often develop neurogenic
supine hypertension (nSH), ie, high blood pressure (BP) in the supine position, which falls in …

Abnormal aggregates of the synaptic protein, α-synuclein, are the dominant pathology in
syndromes known as the synucleinopathies. The cellular aggregation of the protein occurs …

Clinical diagnosis of multiple system atrophy is challenging and many patients with Lewy
body disease (ie Parkinson's disease or dementia with Lewy bodies) or progressive …

Multiple system atrophy (MSA) is an orphan, fatal, adult-onset neurodegenerative disorder of
uncertain etiology that is clinically characterized by various combinations of parkinsonism …

Background In preclinical studies, davunetide promoted microtubule stability and reduced
tau phosphorylation. Because progressive supranuclear palsy (PSP) is linked to tau …

Multiple system atrophy (MSA) may be difficult to distinguish clinically from other disorders,
particularly in the early stages of the disease. An autonomic-only presentation can be …

Z. Ahmed, YT Asi, A. Sailer, AJ Lees, H. Houlden, T. Revesz and JL Holton (2012)
Neuropathology and Applied Neurobiology38, 4–24 The neuropathology, pathophysiology …