The eukaryotic genome is organized in the three-dimensional nuclear space in a specific
manner that is both a cause and a consequence of its function. This organization is partly …

The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

The functional importance of gene enhancers in regulated gene expression is well
established,,. In addition to widespread transcription of long non-coding RNAs (lncRNAs) in …

The remarkable phenotypic diversity of β thalassemia that range from severe anemia and
transfusion-dependency, to a clinically asymptomatic state exemplifies how a spectrum of …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

The fetal-to-adult hemoglobin switch and silencing of fetal hemoglobin (HbF) have been
areas of long-standing interest among hematologists, given the fact that clinical induction of …

Accurate control of gene expression in the right cell at the right moment is of fundamental
importance to animal development and homeostasis. At the heart of gene regulation lie the …

In humans, nearly two meters of genomic material must be folded to fit inside each
micrometer-scale cell nucleus while remaining accessible for gene transcription, DNA …

CTCF has it all. The transcription factor binds to tens of thousands of genomic sites, some
tissue-specific, others ultra-conserved. It can act as a transcriptional activator, repressor and …

Enhancers establish spatial or temporal patterns of gene expression that are critical for
development, yet our understanding of how these DNA cis-regulatory elements function from …