The hippo pathway effectors YAP/TAZ-TEAD oncoproteins as emerging therapeutic targets in the tumor microenvironment
Simple Summary YAP/TAZ are the central effectors of the Hippo pathway and orchestrate
their oncogenic program by binding to TEAD transcriptional factors. Here, we document a …
their oncogenic program by binding to TEAD transcriptional factors. Here, we document a …
Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancer
Rauvolfia tetraphylla is an essential medicinal plant that has been widely used in traditional
medicine for various disease treatments. However, the tumor suppressor activity of R …
medicine for various disease treatments. However, the tumor suppressor activity of R …
pathclip: Detection of genes and gene relations from biological pathway figures through image-text contrastive learning
In biomedical literature, biological pathways are commonly described through a combination
of images and text. These pathways contain valuable information, including genes and their …
of images and text. These pathways contain valuable information, including genes and their …
DNA methylation-mediated energy metabolism provides new insight into the quality losses during oyster reproductive process
X Wang, Y Wei, R Cong, W Wang, H Qi, G Zhang… - Aquaculture, 2024 - Elsevier
Excessive energy consumption during reproductive process seriously reduces the nutritive
value of oysters. Significant reduction of meat quality was detected in condition index and …
value of oysters. Significant reduction of meat quality was detected in condition index and …
Deep learning uncovers histological patterns of YAP1/TEAD activity related to disease aggressiveness in cancer patients
Over the last decade, Hippo signaling has emerged as a major tumor-suppressing pathway.
Its dysregulation is associated with abnormal expression of YAP1 and TEAD-family genes …
Its dysregulation is associated with abnormal expression of YAP1 and TEAD-family genes …
miRNA deregulation and relationship with metabolic parameters after Mediterranean dietary intervention in BRCA-mutated women
S De Summa, D Traversa, A Daniele… - Frontiers in …, 2023 - frontiersin.org
Background Breast cancer onset is determined by a genetics-environment interaction.
BRCA1/2 gene alterations are often genetically shared in familial context, but also food …
BRCA1/2 gene alterations are often genetically shared in familial context, but also food …
Verteporfin Suppresses YAP-Induced Glycolysis in Breast Cancer Cells
H Chen, LF Zhang, Y Miao, Y **, X Li… - Journal of …, 2023 - Taylor & Francis
Objective The inhibition of the Hippo pathway through targeting the Yes-associated protein
(YAP) presents a novel and promising approach for treating tumors. However, the efficacy of …
(YAP) presents a novel and promising approach for treating tumors. However, the efficacy of …
In search of epigenetic hallmarks of different tissues: an integrative omics study of horse liver, lung, and heart
DNA methylation and microRNA (miRNA) expression are epigenetic mechanisms essential
for regulating tissue-specific gene expression and metabolic processes. However, high …
for regulating tissue-specific gene expression and metabolic processes. However, high …
Ring finger protein 128 promotes, rather than inhibits, colorectal cancer progression by regulating the Hippo signaling pathway
S Ning, Y Chen, G Wang, Y Liu, Y Yang… - Frontiers in …, 2022 - frontiersin.org
Background Colorectal cancer is a common malignancy of the gastrointestinal tract, and its
incidence and mortality rates have increased in recent years. RNF128 is an E3 ubiquitin …
incidence and mortality rates have increased in recent years. RNF128 is an E3 ubiquitin …
miR-564 and miR-718 expressions are downregulated in colorectal cancer tissues
D Mihcioglu, E Elihan, A Aytekin… - Turkish Journal of …, 2023 - degruyter.com
Objectives MicroRNAs (miRNAs) are small RNAs that are involved in regulating gene
expression and have an important role in biological pathways such as differentiation …
expression and have an important role in biological pathways such as differentiation …