The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics
Brain cancer, especially the most common type of glioblastoma, is highly invasive and
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …
[HTML][HTML] Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies
L Han, C Jiang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Blood–brain barrier (BBB) strictly controls matter exchange between blood and brain, and
severely limits brain penetration of systemically administered drugs, resulting in ineffective …
severely limits brain penetration of systemically administered drugs, resulting in ineffective …
[HTML][HTML] Nanocarrier-based drug combination therapy for glioblastoma
The current achievements in treating glioblastoma (GBM) patients are not sufficient because
many challenges exist, such as tumor heterogeneity, the blood brain barrier, glioma stem …
many challenges exist, such as tumor heterogeneity, the blood brain barrier, glioma stem …
Through scalp and skull NIR‐II photothermal therapy of deep orthotopic brain tumors with precise photoacoustic imaging guidance
Brain tumor is one of the most lethal cancers owing to the existence of blood–brain barrier
and blood–brain tumor barrier as well as the lack of highly effective brain tumor treatment …
and blood–brain tumor barrier as well as the lack of highly effective brain tumor treatment …
Bright aggregation‐induced‐emission dots for targeted synergetic NIR‐II fluorescence and NIR‐I photoacoustic imaging of orthotopic brain tumors
Precise diagnostics are of significant importance to the optimal treatment outcomes of
patients bearing brain tumors. NIR‐II fluorescence imaging holds great promise for brain …
patients bearing brain tumors. NIR‐II fluorescence imaging holds great promise for brain …
Nanomedicine for brain cancer
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
Rethinking CRITID procedure of brain targeting drug delivery: circulation, blood brain barrier recognition, intracellular transport, diseased cell targeting, internalization …
The past decades have witnessed great progress in nanoparticle (NP)‐based brain‐
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …
Targeted delivery of CRISPR/Cas9‐mediated cancer gene therapy via liposome‐templated hydrogel nanoparticles
Due to its simplicity, versatility, and high efficiency, the clustered regularly interspaced short
palindromic repeat (CRISPR)/Cas9 technology has emerged as one of the most promising …
palindromic repeat (CRISPR)/Cas9 technology has emerged as one of the most promising …
Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy
The clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-
associated protein (Cas) systems are efficient and versatile gene editing tools, which offer …
associated protein (Cas) systems are efficient and versatile gene editing tools, which offer …