Soil microbiome engineering for sustainability in a changing environment

JK Jansson, R McClure, RG Egbert - Nature Biotechnology, 2023 - nature.com
Recent advances in microbial ecology and synthetic biology have the potential to mitigate
damage caused by anthropogenic activities that are deleteriously impacting Earth's soil …

Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials

S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

Designing microbial cell factories for the production of chemicals

JS Cho, GB Kim, H Eun, CW Moon, SY Lee - Jacs Au, 2022 - ACS Publications
The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

[HTML][HTML] Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup… - Nature Reviews …, 2021 - nature.com
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Mining genomes to illuminate the specialized chemistry of life

MH Medema, T de Rond, BS Moore - Nature Reviews Genetics, 2021 - nature.com
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Microbiome engineering: synthetic biology of plant-associated microbiomes in sustainable agriculture

J Ke, B Wang, Y Yoshikuni - Trends in Biotechnology, 2021 - cell.com
To support an ever-increasing population, modern agriculture faces numerous challenges
that pose major threats to global food and energy security. Plant-associated microbes, with …

Step** on the gas to a circular economy: accelerating development of carbon-negative chemical production from gas fermentation

N Fackler, BD Heijstra, BJ Rasor… - Annual Review of …, 2021 - annualreviews.org
Owing to rising levels of greenhouse gases in our atmosphere and oceans, climate change
poses significant environmental, economic, and social challenges globally. Technologies …

High-throughput genetic engineering of nonmodel and undomesticated bacteria via iterative site-specific genome integration

JR Elmore, GN Dexter, H Baldino, JD Huenemann… - Science …, 2023 - science.org
Efficient genome engineering is critical to understand and use microbial functions. Despite
recent development of tools such as CRISPR-Cas gene editing, efficient integration of …

Engineering rhizobacteria for sustainable agriculture

TL Haskett, A Tkacz, PS Poole - The ISME Journal, 2021 - academic.oup.com
Exploitation of plant growth promoting (PGP) rhizobacteria (PGPR) as crop inoculants could
propel sustainable intensification of agriculture to feed our rapidly growing population …

Metabolic engineering of Cupriavidus necator H16 for sustainable biofuels from CO2

J Panich, B Fong, SW Singer - Trends in Biotechnology, 2021 - cell.com
Decelerating global warming is one of the predominant challenges of our time and will
require conversion of CO 2 to usable products and commodity chemicals. Of particular …