[HTML][HTML] Red blood cell storage lesion: causes and potential clinical consequences
T Yoshida, M Prudent, A D'Alessandro - Blood Transfusion, 2019 - ncbi.nlm.nih.gov
Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …
Intravascular hemolysis and the pathophysiology of sickle cell disease
Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …
A review of dietary phytochemicals and their relation to oxidative stress and human diseases
R Guan, Q Van Le, H Yang, D Zhang, H Gu, Y Yang… - Chemosphere, 2021 - Elsevier
Phytochemicals refer to active substances in plant-based diets. Phytochemicals found in for
example fruits, vegetables, grains and seed oils are considered relatively safe for …
example fruits, vegetables, grains and seed oils are considered relatively safe for …
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
JD Belcher, C Chen, J Nguyen… - Blood, The Journal …, 2014 - ashpublications.org
Abstract Treatment of sickle cell disease (SCD) is hampered by incomplete understanding of
pathways linking hemolysis to vaso-occlusion. We investigated these pathways in …
pathways linking hemolysis to vaso-occlusion. We investigated these pathways in …
Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins
Hemolysis occurs in many hematologic and nonhematologic diseases. Extracellular
hemoglobin (Hb) has been found to trigger specific pathophysiologies that are associated …
hemoglobin (Hb) has been found to trigger specific pathophysiologies that are associated …
Hemolysis, free hemoglobin toxicity, and scavenger protein therapeutics
F Vallelian, PW Buehler… - Blood, The Journal of the …, 2022 - ashpublications.org
During hemolysis, erythrophagocytes dispose damaged red blood cells. This prevents the
extracellular release of hemoglobin, detoxifies heme, and recycles iron in a linked metabolic …
extracellular release of hemoglobin, detoxifies heme, and recycles iron in a linked metabolic …
Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion
Background—Intravascular red cell hemolysis impairs nitric oxide (NO)–redox homeostasis,
producing endothelial dysfunction, platelet activation, and vasculopathy. Red blood cell …
producing endothelial dysfunction, platelet activation, and vasculopathy. Red blood cell …
Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes
Hemolysis, long discounted as a critical measure of sickle cell disease severity when
compared with sickle vaso-occlusion, may be the proximate cause of some disease …
compared with sickle vaso-occlusion, may be the proximate cause of some disease …
Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development
Hemolysis, which occurs in many disease states, can trigger a diverse pathophysiologic
cascade that is related to the specific biochemical activities of free Hb and its porphyrin …
cascade that is related to the specific biochemical activities of free Hb and its porphyrin …
Mechanisms of haemolysis-induced kidney injury
K Van Avondt, E Nur, S Zeerleder - Nature Reviews Nephrology, 2019 - nature.com
Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …
haemolytic anaemias, including those associated with haemoglobinopathies, complement …