The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …

Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …

Metabolites, the biochemical products of the cellular process, can be used to measure
alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease …

Age-related macular degeneration (AMD) is the leading cause of vision loss in the western
world. Recent evidence suggests that RPE and photoreceptors have an interconnected …

Prolonged survival of a typical postmitotic neuron hinges on a balance between multiple
processes, among these are a sustenance of ATP production and protection against reactive …

Alzheimer's disease (AD) is the most common age-related dementia. The alteration in
metabolic characteristics determines the prognosis. Patients at risk show reduced glucose …

Alzheimer's disease (AD) is the most common form of age-related dementia. Despite
decades of research, the etiology and pathogenesis of AD are not well understood. Brain …

Reactive oxygen species (ROS) are recognized both as damaging molecules and
intracellular signaling entities. In addition to its role in ATP generation, the mitochondrial …

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder with a complex
pathophysiology. Type 2 diabetes (T2D) is a strong risk factor for AD that shares similar …

Mitochondria are key organelles for brain health. Mitochondrial alterations have been
reported in several neurodegenerative disorders, including Alzheimer's disease (AD), and …