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Signaling pathways in rheumatoid arthritis: implications for targeted therapy
Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …
progression leads to joint deformity and associated loss of function, which significantly …
Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies
AL Mueller, Z Payandeh, N Mohammadkhani… - Cells, 2021 - mdpi.com
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …
progressive autoimmune disease affecting many people worldwide. While patients show …
Rheumatoid arthritis: pathogenesis and therapeutic advances
Y Gao, Y Zhang, X Liu - MedComm, 2024 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the unresolved
synovial inflammation for tissues‐destructive consequence, which remains one of significant …
synovial inflammation for tissues‐destructive consequence, which remains one of significant …
[HTML][HTML] Histone deacetylases and their inhibitors in inflammatory diseases
SY Zhang, LY Zhang, R Wen, N Yang… - Biomedicine & …, 2024 - Elsevier
Despite considerable research efforts, inflammatory diseases remain a heavy burden on
human health, causing significant economic losses annually. Histone deacetylases …
human health, causing significant economic losses annually. Histone deacetylases …
New targets and strategies for rheumatoid arthritis: from signal transduction to epigenetic aspect
M Zhu, Q Ding, Z Lin, R Fu, F Zhang, Z Li, M Zhang… - Biomolecules, 2023 - mdpi.com
Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to joint damage
and even permanent disability, seriously affecting patients' quality of life. At present, the …
and even permanent disability, seriously affecting patients' quality of life. At present, the …
[HTML][HTML] Exploring the therapeutic potential of regulatory T cell in rheumatoid arthritis: Insights into subsets, markers, and signaling pathways
QY Su, HC Li, XJ Jiang, ZQ Jiang, Y Zhang… - Biomedicine & …, 2024 - Elsevier
Rheumatoid arthritis (RA) is a complex autoimmune inflammatory rheumatic disease
characterized by an imbalance between immunological reactivity and immune tolerance …
characterized by an imbalance between immunological reactivity and immune tolerance …
Epigenetic regulation in the pathogenesis of rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease. The etiology of RA remains
undetermined and the pathogenesis is complex. There remains a paucity of ideal …
undetermined and the pathogenesis is complex. There remains a paucity of ideal …
[HTML][HTML] Critical functions of histone deacetylases (HDACs) in modulating inflammation associated with cardiovascular diseases
S Kulthinee, N Yano, S Zhuang, L Wang, TC Zhao - Pathophysiology, 2022 - mdpi.com
Histone deacetylases (HDACs) are a superfamily of enzymes that catalyze the removal of
acetyl functional groups from lysine residues of histone and non-histone proteins. There are …
acetyl functional groups from lysine residues of histone and non-histone proteins. There are …
Histone Deacetylases (HDACs) Roles in Inflammation-mediated Diseases; Current Knowledge
The histone acetyl transferases (HATs) and histone deacetylases (HDACs), which are
mostly recognized for their involvement in regulating chromatin remodeling via histone …
mostly recognized for their involvement in regulating chromatin remodeling via histone …
[HTML][HTML] An update on epigenetic regulation in autoimmune diseases
X Mei, B Zhang, M Zhao, Q Lu - Journal of Translational Autoimmunity, 2022 - Elsevier
Autoimmune diseases (AIDs) generally manifest as chronic immune disorders characterized
by significant heterogeneity and complex symptoms. The discordant incidence of AIDs …
by significant heterogeneity and complex symptoms. The discordant incidence of AIDs …