Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies

AL Mueller, Z Payandeh, N Mohammadkhani… - Cells, 2021 - mdpi.com
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

Rheumatoid arthritis: pathogenesis and therapeutic advances

Y Gao, Y Zhang, X Liu - MedComm, 2024 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the unresolved
synovial inflammation for tissues‐destructive consequence, which remains one of significant …

[HTML][HTML] Histone deacetylases and their inhibitors in inflammatory diseases

SY Zhang, LY Zhang, R Wen, N Yang… - Biomedicine & …, 2024 - Elsevier
Despite considerable research efforts, inflammatory diseases remain a heavy burden on
human health, causing significant economic losses annually. Histone deacetylases …

New targets and strategies for rheumatoid arthritis: from signal transduction to epigenetic aspect

M Zhu, Q Ding, Z Lin, R Fu, F Zhang, Z Li, M Zhang… - Biomolecules, 2023 - mdpi.com
Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to joint damage
and even permanent disability, seriously affecting patients' quality of life. At present, the …

[HTML][HTML] Exploring the therapeutic potential of regulatory T cell in rheumatoid arthritis: Insights into subsets, markers, and signaling pathways

QY Su, HC Li, XJ Jiang, ZQ Jiang, Y Zhang… - Biomedicine & …, 2024 - Elsevier
Rheumatoid arthritis (RA) is a complex autoimmune inflammatory rheumatic disease
characterized by an imbalance between immunological reactivity and immune tolerance …

Epigenetic regulation in the pathogenesis of rheumatoid arthritis

C Yang, D Li, D Teng, Y Zhou, L Zhang… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease. The etiology of RA remains
undetermined and the pathogenesis is complex. There remains a paucity of ideal …

[HTML][HTML] Critical functions of histone deacetylases (HDACs) in modulating inflammation associated with cardiovascular diseases

S Kulthinee, N Yano, S Zhuang, L Wang, TC Zhao - Pathophysiology, 2022 - mdpi.com
Histone deacetylases (HDACs) are a superfamily of enzymes that catalyze the removal of
acetyl functional groups from lysine residues of histone and non-histone proteins. There are …

Histone Deacetylases (HDACs) Roles in Inflammation-mediated Diseases; Current Knowledge

SA Jasim, FMA Altalbawy, M Abohassan… - Cell Biochemistry and …, 2024 - Springer
The histone acetyl transferases (HATs) and histone deacetylases (HDACs), which are
mostly recognized for their involvement in regulating chromatin remodeling via histone …

[HTML][HTML] An update on epigenetic regulation in autoimmune diseases

X Mei, B Zhang, M Zhao, Q Lu - Journal of Translational Autoimmunity, 2022 - Elsevier
Autoimmune diseases (AIDs) generally manifest as chronic immune disorders characterized
by significant heterogeneity and complex symptoms. The discordant incidence of AIDs …