Oral cancer is one of the most common cancers worldwide. Despite easy access to the oral
cavity and significant advances in treatment, the morbidity and mortality rates for oral cancer …

Background Improving our understanding of cancer and other complex diseases requires
integrating diverse data sets and algorithms. Intertwining in vivo and in vitro data and in …

Pathology is essential for research in disease and development, as well as for clinical
decision making. For more than 100 years, pathology practice has involved analyzing …

Optical chemical imaging seeks to nondestructively acquire spatially resolved chemical
information without the use of labels or probes. The combination of vibrational mid-infrared …

Current methods for cancer detection rely on tissue biopsy, chemical labeling/staining, and
examination of the tissue by a pathologist. Though these methods continue to remain the …

In recent years, the application of vibrational spectroscopy in biomedical research has
rapidly expanded; covering aspects of pharmaceutical development, to point-of-care …

Tumor grade assessment is critical to the treatment of cancers. A pathologist typically
evaluates grade by examining morphologic organization in tissue using hematoxylin and …

Fourier transform infrared (FT-IR) spectroscopic imaging has been widely tested as a tool for
stainless digital histology of biomedical specimens, including for the identification of …

The structure and organization of a tumor and its microenvironment are often associated
with cancer outcomes due to spatially varying molecular composition and signaling. A …

Histological stains, such as hematoxylin and eosin (H&E), are routinely used in clinical
diagnosis and research. While these labels offer a high degree of specificity, throughput is …