Ecology and evolution of antimicrobial resistance in bacterial communities

MJ Bottery, JW Pitchford, VP Friman - The ISME Journal, 2021‏ - academic.oup.com
Accumulating evidence suggests that the response of bacteria to antibiotics is significantly
affected by the presence of other interacting microbes. These interactions are not typically …

Mechanisms of antimicrobial resistance in biofilms

HY Liu, EL Prentice, MA Webber - npj Antimicrobials and Resistance, 2024‏ - nature.com
Most bacteria in nature exist in aggregated communities known as biofilms, and cells within
a biofilm demonstrate major physiological changes compared to their planktonic …

Modifying and reacting to the environmental pH can drive bacterial interactions

C Ratzke, J Gore - PLoS biology, 2018‏ - journals.plos.org
Microbes usually exist in communities consisting of myriad different but interacting species.
These interactions are typically mediated through environmental modifications; microbes …

Paneth cell-derived lysozyme defines the composition of mucolytic microbiota and the inflammatory tone of the intestine

S Yu, I Balasubramanian, D Laubitz, K Tong… - Immunity, 2020‏ - cell.com
Paneth cells are the primary source of C-type lysozyme, a β-1, 4-N-
acetylmuramoylhydrolase that enzymatically processes bacterial cell walls. Paneth cells are …

Silver nanoparticles with different size and shape: equal cytotoxicity, but different antibacterial effects

J Helmlinger, C Sengstock, C Groß-Heitfeld, C Mayer… - RSC …, 2016‏ - pubs.rsc.org
The influence of silver nanoparticle morphology on the dissolution kinetics in ultrapure water
as well as the biological effect on eukaryotic and prokaryotic cells was examined. Silver …

Antimicrobial activity and resistance: influencing factors

J Li, S ** Up High Standards
C Hirsch, S Schildknecht - Frontiers in pharmacology, 2019‏ - frontiersin.org
Concern regarding the reproducibility of observations in life science research has emerged
in recent years, particularly in view of unfavorable experiences with preclinical in vivo …

Inter-species interactions alter antibiotic efficacy in bacterial communities

MJ Bottery, JL Matthews, AJ Wood… - The ISME …, 2022‏ - academic.oup.com
The efficacy of antibiotic treatments targeting polymicrobial communities is not well predicted
by conventional in vitro susceptibility testing based on determining minimum inhibitory …

Pharmacokinetics and pharmacodynamics of antibacterial agents

ME Levison, JH Levison - Infectious disease clinics of North …, 2009‏ - pmc.ncbi.nlm.nih.gov
The pharmacodynamics of an antimicrobial drug relates its pharmacokinetics to the time
course of the antimicrobial effects at the site of the infection. Knowledge of the drug's …

The toxic effect of silver ions and silver nanoparticles towards bacteria and human cells occurs in the same concentration range

C Greulich, D Braun, A Peetsch, J Diendorf, B Siebers… - RSC …, 2012‏ - pubs.rsc.org
Silver is commonly used both in ionic form and in nanoparticulate form as a bactericidal
agent. This is generally ascribed to a higher toxicity towards prokaryotic cells than towards …