The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …

Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …

Human pluripotent stem cells (hPSCs) offer the potential to generate large numbers of
functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that …

We re-examine the individual components for human embryonic stem cell (ESC) and
induced pluripotent stem cell (iPSC) culture and formulate a cell culture system in which all …

Synaptic loss is the cardinal feature linking neuropathology to cognitive decline in
Alzheimer's disease (AD). However, the mechanism of synaptic damage remains …

Hydrogen sulfide is a highly toxic gas—second only to carbon monoxide as a cause of
inhalational deaths. Its mechanism of toxicity is only partially known and no specific therapy …

Epithelial-to-mesenchymal transition (EMT) is a developmental process important for cell
fate determination. Fibroblasts, a product of EMT, can be reset into induced pluripotent stem …

Parkinson's disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the
substantia nigra pars compacta (SNpc). An association has been reported between PD and …

The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) offers an
opportunity to generate pluripotent patient-specific cell lines that can help model human …