T Regulatory cells (Tregs) can have both protective and pathological roles. They maintain
immune homeostasis and inhibit immune responses in various diseases, including cancer …

Tumor-infiltrating lymphocytes (TILs) are an important histopathologic feature of colorectal
cancer that confer prognostic information. Previous clinical and epidemiologic studies have …

The outstanding clinical success of immune checkpoint blockade has revived the interest in
underlying mechanisms of the immune system that are capable of eliminating tumors even …

The therapeutic potential of host-specific and tumour-specific immune responses is well
recognized and, after many years, active immunotherapies directed at inducing or …

T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and
tumor-infiltrating Tregs are often associated with a poor clinical outcome. Tregs are potent …

Liver metastases remain a major barrier to successful management of malignant disease,
particularly for cancers of the gastrointestinal tract but also for other malignancies, such as …

It has recently become clear that the tumour microenvironment, and in particular the immune
system, has a crucial role in modulating tumour progression and response to therapy …

Colorectal cancer (CRC) remains a leading cause of cancer-related deaths in the United
States. Although immunotherapy has dramatically changed the landscape of treatment for …

Abstract CD8+ tumor-infiltrating lymphocytes (TIL) are associated with survival in a variety of
cancers. A second subpopulation of TIL, defined by forkhead box protein P3 (FoxP3) …

Background: The role of tumour-infiltrating inflammation in the prognosis of patients with
colorectal cancer (CRC) has not been fully evaluated. The primary objective of our meta …