T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

Antibody-mediated neutralization of SARS-CoV-2

H Gruell, K Vanshylla, T Weber, CO Barnes, C Kreer… - Immunity, 2022 - cell.com
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …

T cell responses to SARS-CoV-2 spike cross-recognize Omicron

R Keeton, MB Tincho, A Ngomti, R Baguma, N Benede… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant (B. 1.1. 529) has multiple spike protein
mutations, that contribute to viral escape from antibody neutralization,,–and reduce vaccine …

[HTML][HTML] SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron

A Tarke, CH Coelho, Z Zhang, JM Dan, ED Yu… - Cell, 2022 - cell.com
We address whether T cell responses induced by different vaccine platforms (mRNA-1273,
BNT162b2, Ad26. COV2. S, and NVX-CoV2373) cross-recognize early SARS-CoV-2 …

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

S Cele, L Jackson, DS Khoury, K Khan, T Moyo-Gwete… - Nature, 2022 - nature.com
The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B. 1.1. 529),
first identified in Botswana and South Africa, may compromise vaccine effectiveness and …

Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients

CH GeurtsvanKessel, D Geers, KS Schmitz… - Science …, 2022 - science.org
The severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) Omicron
variant is spreading rapidly, even in vaccinated individuals, raising concerns about immune …

Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants

TA Bates, SK McBride, HC Leier, G Guzman… - Science …, 2022 - science.org
Current coronavirus disease 2019 (COVID-19) vaccines effectively reduce overall morbidity
and mortality and are vitally important to controlling the pandemic. Individuals who …

[HTML][HTML] Breakthrough infections with SARS-CoV-2 omicron despite mRNA vaccine booster dose

C Kuhlmann, CK Mayer, M Claassen, T Maponga… - The Lancet, 2022 - thelancet.com
A group of German visitors who had received three doses of SARS-CoV-2 vaccines,
including at least two doses of an mRNA vaccine, experienced breakthrough infections with …

[HTML][HTML] SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection

S Cele, L Jackson, DS Khoury, K Khan, T Moyo-Gwete… - MedRxiv, 2021 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 Omicron, first identified in Botswana and South Africa, may
compromise vaccine effectiveness and the ability of antibodies triggered by previous …

Final analysis of efficacy and safety of single-dose Ad26. COV2. S

J Sadoff, G Gray, A Vandebosch… - … England Journal of …, 2022 - Mass Medical Soc
Abstract Background The Ad26. COV2. S vaccine was highly effective against severe–
critical coronavirus disease 2019 (Covid-19), hospitalization, and death in the primary phase …