Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …

Harnessing the process of natural selection to obtain and understand new microbial
phenotypes has become increasingly possible due to advances in culturing techniques …

Controlled experimental evolution during antibiotic treatment can help to explain the
processes leading to antibiotic resistance in bacteria. Recently, intermittent antibiotic …

For most of human history, bacterial pathogens have been a major cause of disease and
mortality. The development of antibiotics provided a simple and effective treatment for …

Antimicrobial efficacy, which is central to many aspects of medicine, is being rapidly eroded
by bacterial resistance. Since new resistance can be induced by antimicrobial action, highly …

The agricultural ecosystem creates a platform for the development and dissemination of
antimicrobial resistance, which is promoted by the indiscriminate use of antibiotics in the …

Whole-genome sequencing (WGS) has been vital for revealing the rapid temporal and
spatial evolution of antimicrobial resistance (AMR) in bacterial pathogens. Some …

In multiple myeloma malignant plasma cells expand within the bone marrow. Since this site
is well-perfused, a rapid dissemination of “fitter” clones may be anticipated. However, an …

Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …

Antibiotic resistance is one of the major causes of morbidity and mortality, triggered by the
adhesion of microbes and to some extent the formation of biofilms. This condition has been …