Hepatitis C virus infection

MP Manns, M Buti, ED Gane, JM Pawlotsky… - Nature reviews Disease …, 2017 - nature.com
Hepatitis C virus (HCV) is a hepatotropic RNA virus that causes progressive liver damage,
which might result in liver cirrhosis and hepatocellular carcinoma. Globally, between 64 and …

Tight junction proteins in gastrointestinal and liver disease

MB Zeisel, P Dhawan, TF Baumert - Gut, 2019 - gut.bmj.com
Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …

Anti‐infective properties of epigallocatechin‐3‐gallate (EGCG), a component of green tea

J Steinmann, J Buer, T Pietschmann… - British journal of …, 2013 - Wiley Online Library
The consumption of green tea (C amellia sinensis) has been shown to have many
physiological and pharmacological health benefits. In the past two decades several studies …

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels

C Ko, A Chakraborty, WM Chou, J Hasreiter… - Journal of …, 2018 - Elsevier
Background & Aims Several steps in the HBV life cycle remain obscure because of a lack of
robust in vitro infection models. These steps include particle entry, formation and …

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

TKH Scheel, CM Rice - Nature medicine, 2013 - nature.com
More than two decades of intense research has provided a detailed understanding of
hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has …

Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90

TN Bukong, F Momen-Heravi, K Kodys, S Bala… - PLoS …, 2014 - journals.plos.org
Antibodies targeting receptor-mediated entry of HCV into hepatocytes confer limited
therapeutic benefits. Evidence suggests that exosomes can transfer genetic materials …

Immune responses and immunopathology in acute and chronic viral hepatitis

EC Shin, PS Sung, SH Park - Nature Reviews Immunology, 2016 - nature.com
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …

Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7. 5 cells

V Ramakrishnaiah, C Thumann, I Fofana… - Proceedings of the …, 2013 - pnas.org
Recent evidence indicates there is a role for small membrane vesicles, including exosomes,
as vehicles for intercellular communication. Exosomes secreted by most cell types can …

The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control

J Bukh - Journal of hepatology, 2016 - Elsevier
The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …

Recent advances in hepatocellular carcinoma therapy

R Dutta, RI Mahato - Pharmacology & therapeutics, 2017 - Elsevier
Hepatocellular carcinoma (HCC), also called malignant hepatoma, is one of the deadliest
cancers due to its complexities, reoccurrence after surgical resection, metastasis and …