The development of antiretroviral drugs (ARVs) was a great milestone in the management of
HIV infection. ARVs suppress viral activity in the host cell, thus minimizing injury to the cells …

CD8+ T cells are the key executioners of the adaptive immune arm, which mediates
antitumor and antiviral immunity. Naïve CD8+ T cells develop in the thymus and are quickly …

Oncogene-induced senescence causes hepatocytes to secrete cytokines, which induce their
immune-mediated clearance to prevent tumor initiation, a process termed" senescence …

Summary The Aryl hydrocarbon receptor (Ahr) regulates the differentiation and function of
CD4+ T cells; however, its cell-intrinsic role in CD8+ T cells remains elusive. Herein we …

Chronic infections and cancers evade the host immune system through mechanisms that
induce T cell exhaustion. The heterogeneity within the exhausted CD8+ T cell pool has …

Immunotherapy has revolutionized the treatment of cancer in recent years and achieved
overall success and long‐term clinical benefit in patients with a wide variety of cancer types …

Currently, immunotherapy targeting programmed cell death 1 (PD-1) or programmed death
ligand 1 (PD-L1) has revolutionized the treatment strategy of human cancer patients …

Simple Summary T cells infiltrating in the tumor microenvironment play a critical role in anti-
tumor immunity. A well-balanced metabolism in T cells determine their function and fate. In …

Immune memory cells are poised to rapidly expand and elaborate effector functions upon
reinfection yet exist in a functionally quiescent state. The paradigm is that memory T cells …

ABSTRACT Background/Purpose: Ageing has profound impact on the immune system,
mainly on T-cells. However, it has been suggested that chronic exercise may delay …