Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …
either promoters or inhibitors of cell death. The functional interplay and balance between the …
The cell biology of mitochondrial membrane dynamics
M Giacomello, A Pyakurel, C Glytsou… - Nature reviews Molecular …, 2020 - nature.com
Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …
mitochondria are often considered the 'powerhouses of the cell'. However, our …
Two decades of Martini: Better beads, broader scope
The Martini model, a coarse‐grained force field for molecular dynamics simulations, has
been around for nearly two decades. Originally developed for lipid‐based systems by the …
been around for nearly two decades. Originally developed for lipid‐based systems by the …
Sphingolipids in metabolic disease: The good, the bad, and the unknown
The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) are a
recent addition to the lipids accumulated in obesity and have emerged as important …
recent addition to the lipids accumulated in obesity and have emerged as important …
A comprehensive review: sphingolipid metabolism and implications of disruption in sphingolipid homeostasis
BM Quinville, NM Deschenes, AE Ryckman… - International journal of …, 2021 - mdpi.com
Sphingolipids are a specialized group of lipids essential to the composition of the plasma
membrane of many cell types; however, they are primarily localized within the nervous …
membrane of many cell types; however, they are primarily localized within the nervous …
Ceramides in metabolism: key lipotoxic players
B Chaurasia, SA Summers - Annual review of physiology, 2021 - annualreviews.org
The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
ER as master regulator of membrane trafficking and organelle function
EM Wenzel, LA Elfmark, H Stenmark… - Journal of cell biology, 2022 - rupress.org
The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the
cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …
cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …
[HTML][HTML] Apoptosis regulation at the mitochondria membrane level
Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis
that activates the caspase cascade and irreversibly causes the majority of cells to die. The …
that activates the caspase cascade and irreversibly causes the majority of cells to die. The …
Regulation of mammalian mitochondrial dynamics: opportunities and challenges
Mitochondria are highly dynamic organelles and important for a variety of cellular functions.
They constantly undergo fission and fusion events, referred to as mitochondrial dynamics …
They constantly undergo fission and fusion events, referred to as mitochondrial dynamics …
Contribution of specific ceramides to obesity-associated metabolic diseases
P Hammerschmidt, JC Brüning - Cellular and Molecular Life Sciences, 2022 - Springer
Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …