The roles of histone variants in fine-tuning chromatin organization and function
Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …
post-translational modification and chromatin remodelling complexes, histone variants …
Single-cell sequencing of brain cell transcriptomes and epigenomes
Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …
transforming our understanding of the cellular building blocks of neural circuits. By directly …
Activity-regulated transcription: bridging the gap between neural activity and behavior
Gene transcription is the process by which the genetic codes of organisms are read and
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …
[HTML][HTML] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3
Chemical modifications of histones can mediate diverse DNA-templated processes,
including gene transcription,–. Here we provide evidence for a class of histone post …
including gene transcription,–. Here we provide evidence for a class of histone post …
Epigenetics of aging and aging-associated diseases
Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …
Over the past decades, several hallmarks of aging have been defined, including epigenetic …
Epigenetics and aging
Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …
to epigenetic information accompany aging in both dividing and nondividing cells …
Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism
Autism spectrum disorder (ASD) involves substantial genetic contributions. These
contributions are profoundly heterogeneous but may converge on common pathways that …
contributions are profoundly heterogeneous but may converge on common pathways that …
Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation
Histone-modifying enzymes are implicated in the control of diverse DNA-templated
processes including gene expression. Here, we outline historical and current thinking …
processes including gene expression. Here, we outline historical and current thinking …
Gamma entrainment binds higher-order brain regions and offers neuroprotection
Neuronal and synaptic loss is characteristic in many neurodegenerative diseases, such as
frontotemporal dementia and Alzheimer's disease. Recently, we showed that inducing …
frontotemporal dementia and Alzheimer's disease. Recently, we showed that inducing …