Pattern recognition receptors in health and diseases

D Li, M Wu - Signal transduction and targeted therapy, 2021 - nature.com
Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …

COVID-19: immunopathogenesis and Immunotherapeutics

L Yang, S Liu, J Liu, Z Zhang, X Wan… - Signal transduction and …, 2020 - nature.com
The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected …

Mother-to-infant microbial transmission from different body sites shapes the develo** infant gut microbiome

P Ferretti, E Pasolli, A Tett, F Asnicar, V Gorfer, S Fedi… - Cell host & …, 2018 - cell.com
The acquisition and development of the infant microbiome are key to establishing a healthy
host-microbiome symbiosis. The maternal microbial reservoir is thought to play a crucial role …

Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

Y He, L Fu, Y Li, W Wang, M Gong, J Zhang, X Dong… - Cell metabolism, 2021 - cell.com
Recent studies in both mice and humans have suggested that gut microbiota could
modulate tumor responsiveness to chemo-or immunotherapies. However, the underlying …

Dysbiosis and the immune system

M Levy, AA Kolodziejczyk, CA Thaiss… - Nature Reviews …, 2017 - nature.com
Throughout the past century, we have seen the emergence of a large number of
multifactorial diseases, including inflammatory, autoimmune, metabolic, neoplastic and …

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease …

X Wang, G Sun, T Feng, J Zhang, X Huang, T Wang… - Cell research, 2019 - nature.com
Recently, increasing evidence has suggested the association between gut dysbiosis and
Alzheimer's disease (AD) progression, yet the role of gut microbiota in AD pathogenesis …

Antimicrobial properties of chitosan and chitosan derivatives in the treatment of enteric infections

D Yan, Y Li, Y Liu, N Li, X Zhang, C Yan - Molecules, 2021 - mdpi.com
Antibiotics played an important role in controlling the development of enteric infection.
However, the emergence of antibiotic resistance and gut dysbiosis led to a growing interest …

Human gut microbiota in health and disease: Unveiling the relationship

M Afzaal, F Saeed, YA Shah, M Hussain… - Frontiers in …, 2022 - frontiersin.org
The human gut possesses millions of microbes that define a complex microbial community.
The gut microbiota has been characterized as a vital organ forming its multidirectional …

Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism

J Gao, K Xu, H Liu, G Liu, M Bai, C Peng… - Frontiers in cellular and …, 2018 - frontiersin.org
The gut microbiota influences the health of the host, especially with regard to gut immune
homeostasis and the intestinal immune response. In addition to serving as a nutrient …

Signals from the gut microbiota to distant organs in physiology and disease

BO Schroeder, F Bäckhed - Nature medicine, 2016 - nature.com
The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is
fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived …