Allosteric modulation of glycine receptors
Inhibitory (or strychnine sensitive) glycine receptors (GlyRs) are anion‐selective transmitter‐
gated ion channels of the cys‐loop superfamily, which includes among others also the …
gated ion channels of the cys‐loop superfamily, which includes among others also the …
The Concise Guide to PHARMACOLOGY 2013/14: ion channels
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism
Trauma-induced damage to the orbitofrontal cortex (OFC) often results in behavioral
inflexibility and impaired judgment. Human alcoholics exhibit similar cognitive deficits …
inflexibility and impaired judgment. Human alcoholics exhibit similar cognitive deficits …
Positive allosteric modulators of Glycine receptors and their potential use in pain therapies
Glycine receptors are ligand-gated ion channels that mediate synaptic inhibition throughout
the mammalian spinal cord, brainstem, and higher brain regions. They have recently …
the mammalian spinal cord, brainstem, and higher brain regions. They have recently …
Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids
Glycine receptors (GlyRs) are transmitter-gated anion channels of the Cys-loop superfamily
which mediate synaptic inhibition at spinal and selected supraspinal sites. Although they …
which mediate synaptic inhibition at spinal and selected supraspinal sites. Although they …
Functional modulation of glycine receptors by the alkaloid gelsemine
CO Lara, P Murath, B Muñoz… - British journal of …, 2016 - Wiley Online Library
Abstract Background and Purpose Gelsemine is one of the principal alkaloids produced by
the Gelsemium genus of plants belonging to the Loganiaceae family. The extracts of these …
the Gelsemium genus of plants belonging to the Loganiaceae family. The extracts of these …
Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses
It is well accepted that ethanol is able to produce major health and economic problems
associated to its abuse. Because of its intoxicating and addictive properties, it is necessary …
associated to its abuse. Because of its intoxicating and addictive properties, it is necessary …
A common molecular basis for exogenous and endogenous cannabinoid potentiation of glycine receptors
W **ong, X Wu, DM Lovinger, L Zhang - Journal of Neuroscience, 2012 - Soc Neuroscience
Both exogenous and endogenous cannabinoids can allosterically modulate glycine
receptors (GlyRs). However, little is known about the molecular basis of cannabinoid-GlyR …
receptors (GlyRs). However, little is known about the molecular basis of cannabinoid-GlyR …
Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol
IW Glaaser, PA Slesinger - Scientific reports, 2017 - nature.com
Activation of G protein-gated inwardly rectifying potassium (GIRK) channels leads to a
hyperpolarization of the neuron's membrane potential, providing an important component of …
hyperpolarization of the neuron's membrane potential, providing an important component of …
Presence of ethanol‐sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens
Key points The nucleus accumbens (nAc) is involved in addiction‐related behaviour caused
by several drugs of abuse, including alcohol. Glycine receptors (GlyRs) are potentiated by …
by several drugs of abuse, including alcohol. Glycine receptors (GlyRs) are potentiated by …