Mitochondrial protein import: from proteomics to functional mechanisms
Mitochondria contain∼ 1,000 different proteins, most of which are imported from the cytosol.
Two import pathways that direct proteins into the mitochondrial inner membrane and matrix …
Two import pathways that direct proteins into the mitochondrial inner membrane and matrix …
Importing mitochondrial proteins: machineries and mechanisms
Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported
across one or both mitochondrial membranes. There is an amazingly versatile set of …
across one or both mitochondrial membranes. There is an amazingly versatile set of …
Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol
Most of the mitochondrial proteome originates from nuclear genes and is transported into the
mitochondria after synthesis in the cytosol. Complex machineries which maintain the …
mitochondria after synthesis in the cytosol. Complex machineries which maintain the …
Structure of the mitochondrial import gate reveals distinct preprotein paths
The translocase of the outer mitochondrial membrane (TOM) is the main entry gate for
proteins,,–. Here we use cryo-electron microscopy to report the structure of the yeast TOM …
proteins,,–. Here we use cryo-electron microscopy to report the structure of the yeast TOM …
[HTML][HTML] Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis
K von der Malsburg, JM Müller, M Bohnert… - Developmental cell, 2011 - cell.com
The mitochondrial inner membrane consists of two domains, inner boundary membrane and
cristae membrane that are connected by crista junctions. Mitofilin/Fcj1 was reported to be …
cristae membrane that are connected by crista junctions. Mitofilin/Fcj1 was reported to be …
Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species
The generation of reactive oxygen species (ROS) is inevitably linked to life. However, the
precise role of ROS in signalling and specific targets is largely unknown. We perform a …
precise role of ROS in signalling and specific targets is largely unknown. We perform a …
[HTML][HTML] Mitochondrial protein import: common principles and physiological networks
Most mitochondrial proteins are encoded in the nucleus. They are synthesized as precursor
forms in the cytosol and must be imported into mitochondria with the help of different protein …
forms in the cytosol and must be imported into mitochondria with the help of different protein …
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins
U Nowicka, P Chroscicki, K Stroobants, M Sladowska… - Elife, 2021 - elifesciences.org
Mitochondria are organelles with their own genomes, but they rely on the import of nuclear-
encoded proteins that are translated by cytosolic ribosomes. Therefore, it is important to …
encoded proteins that are translated by cytosolic ribosomes. Therefore, it is important to …
Disulfide formation in the ER and mitochondria: two solutions to a common process
The endoplasmic reticulum (ER) was long considered to be the only compartment of the
eukaryotic cell in which protein folding is accompanied by enzyme-catalyzed disulfide bond …
eukaryotic cell in which protein folding is accompanied by enzyme-catalyzed disulfide bond …
How proteins form disulfide bonds
The identification of protein disulfide isomerase, almost 50 years ago, opened the way to the
study of oxidative protein folding. Oxidative protein folding refers to the composite process …
study of oxidative protein folding. Oxidative protein folding refers to the composite process …