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SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …
A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection in humans. Despite several emerging vaccines, there …
coronavirus 2 (SARS-CoV-2) infection in humans. Despite several emerging vaccines, there …
A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses
The current COVID-19 pandemic is caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). We demonstrate that despite the large size of the viral RNA …
coronavirus 2 (SARS-CoV-2). We demonstrate that despite the large size of the viral RNA …
Quantification methods for viruses and virus-like particles applied in biopharmaceutical production processes
Introduction Effective cell-based production processes of virus particles are the foundation
for the global availability of classical vaccines, gene therapeutic vectors, and viral oncolytic …
for the global availability of classical vaccines, gene therapeutic vectors, and viral oncolytic …
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019
(COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to …
(COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to …
Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than
160 million people and resulted in more than 3.3 million deaths, and despite the availability …
160 million people and resulted in more than 3.3 million deaths, and despite the availability …
No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing
A recent study proposed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) hijacks the LINE-1 (L1) retrotransposition machinery to integrate into the DNA of infected …
2) hijacks the LINE-1 (L1) retrotransposition machinery to integrate into the DNA of infected …
Engineered extracellular vesicles directed to the spike protein inhibit SARS-CoV-2
SARS-CoV-2 (CoV-2) viral infection results in COVID-19 disease, which has caused
significant morbidity and mortality worldwide. A vaccine is crucial to curtail the spread of …
significant morbidity and mortality worldwide. A vaccine is crucial to curtail the spread of …
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models
KM Stegmann, A Dickmanns, S Gerber, V Nikolova… - Virus research, 2021 - Elsevier
The search for successful therapies of infections with the coronavirus SARS-CoV-2 is
ongoing. We tested inhibition of host cell nucleotide synthesis as a promising strategy to …
ongoing. We tested inhibition of host cell nucleotide synthesis as a promising strategy to …
Preclinical development of a molecular clamp‐stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2
Objectives Efforts to develop and deploy effective vaccines against severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) continue at pace. Here, we describe rational …
syndrome coronavirus 2 (SARS‐CoV‐2) continue at pace. Here, we describe rational …