The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

L Kooshki, SN Zarneshan, S Fakhri, SZ Moradi… - Phytomedicine, 2023 - Elsevier
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …

Phytochemicals as treatment for allergic asthma: Therapeutic effects and mechanisms of action

SV Jasemi, H Khazaei, MR Morovati, T Joshi, IY Aneva… - Phytomedicine, 2024 - Elsevier
Background Allergic asthma is an inflammatory disease caused by the immune system's
reaction to allergens, inflammation and narrowing of the airways, and the production of more …

Therapeutic targeting of Ras/Raf/MAPK pathway by natural products: a systematic and mechanistic approach for neurodegeneration

MM Gravandi, S Abdian, M Tahvilian, A Iranpanah… - Phytomedicine, 2023 - Elsevier
Background Multiple dysregulated pathways are behind the pathogenesis of
neurodegenerative diseases (NDDs); however, the crucial targets are still unknown …

The exosome-mediated PI3K/Akt/mTOR signaling pathway in neurological diseases

A Iranpanah, L Kooshki, SZ Moradi, L Saso, S Fakhri… - Pharmaceutics, 2023 - mdpi.com
As major public health concerns associated with a rapidly growing aging population,
neurodegenerative diseases (NDDs) and neurological diseases are important causes of …

Targeting cell signaling pathways in lung cancer by bioactive phytocompounds

N Choudhary, S Bawari, JT Burcher, D Sinha, D Tewari… - Cancers, 2023 - mdpi.com
Simple Summary Lung cancer is the leading cause of mortality in cancer patients, causing
an estimated 1.8 million deaths in the year 2020. However, the available therapeutic options …

[HTML][HTML] Flavonoids and their derivatives as DNA topoisomerase inhibitors with anti-cancer activity in various cell models: Exploring a novel mode of action

P Sitarek, A Merecz-Sadowska, J Sikora… - Pharmacological …, 2024 - Elsevier
Flavonoids, a diverse group of plant-derived secondary metabolites, have garnered
significant attention for their potential anti-cancer properties. This review explores the role of …

Nutraceutical Properties of Syringic Acid in Civilization Diseases

I Bartel, I Mandryk, JO Horbańczuk, A Wierzbicka… - Nutrients, 2023 - mdpi.com
Civilization diseases account for a worldwide health issue. They result from daily behavioral,
environmental, and genetic factors. One of the most significant opportunities to prevent and …

Lycopene: total-scale literature landscape analysis of a valuable nutraceutical with numerous potential applications in the promotion of human and animal health

AWK Yeung, N Choudhary… - Animal Science …, 2022 - hau.repository.guildhe.ac.uk
Lycopene intake from tomatoes and other food sources has multiple potential health
benefits. This report aimed to evaluate the current research literature on lycopene …

Stevia (Stevia rebaudiana) Improves Carotenoid Content in Eggs When Fed to Laying Hens

VR Pirgozliev, IM Whiting, K Kljak, SC Mansbridge… - Foods, 2022 - mdpi.com
Stevia rebaudiana Bertoni is a shrub with leaves that have a high concentration of
carotenoids such as lutein and zeaxanthin. Egg yolks are a bioavailable source of lutein and …

The therapeutic potential of quercetin for cigarette smoking–induced chronic obstructive pulmonary disease: a narrative review

K Ding, W Jiang, W Zhan, C **ong… - Therapeutic …, 2023 - journals.sagepub.com
Quercetin is a flavonoid with antioxidant and anti-inflammatory properties. Quercetin has
potentially beneficial therapeutic effects for several diseases, including cigarette smoking …