Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …

Highlights•Natural products contribute more than one-third of all FDA-approved NMEs.•The
absolute number of natural product approvals peaked in the 1990s and has since …

An overview of the marine natural products (MNPs) field is shown, including an update of
FDA-approved drugs and those in clinical trials that can be considered derivatives of MNPs …

BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …

Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …

Microalgae (including the cyanobacteria) are established commercial sources of high-value
chemicals such as β-carotene, astaxanthin, docosahexaenoic acid, eicosahexaenoic acid …

The marine environment harbors a number of macro and micro organisms that have
developed unique metabolic abilities to ensure their survival in diverse and hostile habitats …

Marine bacteria and archaea play key roles in global biogeochemistry. To improve our
understanding of this complex microbiome, we employed single-cell genomics and a …

A major goal in natural product discovery programs is to rapidly dereplicate known entities
from complex biological extracts. We demonstrate here that molecular networking, an …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …