Oncolytic viruses constitute an emerging strategy in immunomodulatory cancer treatment.
The first oncolytic virus, Talimogene laherparepvec (T-VEC), based on herpes simplex virus …

Influenza A viruses (IAV) pose a constant threat to the human population and therefore a
better understanding of their fundamental biology and identification of novel therapeutics is …

Tuberculosis is a major global threat to human health. Since the widely used BCG vaccine is
poorly effective in adults, there is a demand for the development of a new type of boost …

Background Interleukin-15 has become a promising molecule in the context of eliciting an
effective, antitumor immune response because it is able to stimulate cells of the innate and …

Background Patient-derived colorectal cancer (CRC) organoids (PDOs) solely consisting of
malignant cells led to major advances in the understanding of cancer treatments. Yet, a …

Virotherapy involves using therapeutic viruses as a conditionally replicating agent or as a
gene expression platform to induce direct cytotoxic or immune related antitumor activity …

New strategies providing protection against tuberculosis (TB) are still pending. The airborne
nature of Mycobacterium tuberculosis (M. tb) infection assumes that the mucosal delivery of …

Oncolytic viruses are currently established as a novel type of immunotherapy. The challenge
is to safely target oncolytic viruses to tumors. Previously, we have generated influenza A …

Recombinant viral vectors represent one of the most promising platforms for creating a new
generation of vaccines against tuberculosis. We constructed a vaccine candidate based on …

We previously attempted to establish a reporter influenza virus by inserting the gene for the
Venus fluorescent protein into the NS segment of influenza A/Puerto Rico/8/34 (PR8, H1N1) …