The biopharmaceutics classification system (BCS) and the biopharmaceutics drug disposition classification system (BDDCS): beyond guidelines

A Charalabidis, M Sfouni, C Bergström… - International journal of …, 2019 - Elsevier
The recent impact of the Biopharmaceutics Classification System (BCS) and the
Biopharmaceutics Drug Disposition Classification System (BDDCS) on relevant scientific …

PBPK models for the prediction of in vivo performance of oral dosage forms

ES Kostewicz, L Aarons, M Bergstrand… - European Journal of …, 2014 - Elsevier
Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

[SÁCH][B] Develo** solid oral dosage forms: pharmaceutical theory and practice

Y Qiu, Y Chen, GGZ Zhang, L Yu, RV Mantri - 2016 - books.google.com
Develo** Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Second Edition
illustrates how to develop high-quality, safe, and effective pharmaceutical products by …

In vivo methods for drug absorption–comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API …

E Sjögren, B Abrahamsson, P Augustijns… - European Journal of …, 2014 - Elsevier
This review summarizes the current knowledge on anatomy and physiology of the human
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …

The nutritional and pharmacological consequences of obesity surgery

J Stein, C Stier, H Raab… - Alimentary pharmacology & …, 2014 - Wiley Online Library
Background Obesity surgery is acknowledged as a highly effective therapy for morbidly
obese patients. Beneficial short‐term effects on common comorbidities are practically …

Herb-drug interactions and hepatotoxicity

MK Parvez, V Rishi - Current drug metabolism, 2019 - ingentaconnect.com
Background: In recent times, herbals or phytomedicines have become very popular due to
their global acceptance as a complementary and alternative remedy. While modern drugs …

Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans

AS Darwich, U Aslam, DM Ashcroft… - Drug Metabolism and …, 2014 - Elsevier
Due to the rapid turnover of the small intestinal epithelia, the rate at which enterocyte
renewal occurs plays an important role in determining the level of drug-metabolizing …

Integrating the impact of lipophilicity on potency and pharmacokinetic parameters enables the use of diverse chemical space during small molecule drug optimization

RR Miller, M Madeira, HB Wood… - Journal of Medicinal …, 2020 - ACS Publications
Lipophilicity has a dominant effect on many parameters that determine unbound drug
exposure as well as drug potency. Despite this, analysis of a large body of drug data …

Delivery of lipophilic bioactives: assembly, disassembly, and reassembly of lipid nanoparticles

M Yao, H **ao, DJ McClements - Annual review of food science …, 2014 - annualreviews.org
The oral bioavailability of lipophilic bioactive molecules can be greatly increased by
encapsulating them within engineered lipid nanoparticles (ELNs), such as micelles …

Constituents, Pharmacokinetics, and Pharmacology of Gegen-Qinlian Decoction

JZ Lu, D Ye, BL Ma - Frontiers in pharmacology, 2021 - frontiersin.org
Gegen-Qinlian decoction (GQD) is a classic traditional Chinese medicine (TCM) formula. It is
composed of four TCMs, including Puerariae Lobatae Radix, Scutellariae Radix, Coptidis …