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The biopharmaceutics classification system (BCS) and the biopharmaceutics drug disposition classification system (BDDCS): beyond guidelines
A Charalabidis, M Sfouni, C Bergström… - International journal of …, 2019 - Elsevier
The recent impact of the Biopharmaceutics Classification System (BCS) and the
Biopharmaceutics Drug Disposition Classification System (BDDCS) on relevant scientific …
Biopharmaceutics Drug Disposition Classification System (BDDCS) on relevant scientific …
PBPK models for the prediction of in vivo performance of oral dosage forms
ES Kostewicz, L Aarons, M Bergstrand… - European Journal of …, 2014 - Elsevier
Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …
upon numerous factors including the physicochemical properties of the drug, characteristics …
[SÁCH][B] Develo** solid oral dosage forms: pharmaceutical theory and practice
Develo** Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Second Edition
illustrates how to develop high-quality, safe, and effective pharmaceutical products by …
illustrates how to develop high-quality, safe, and effective pharmaceutical products by …
In vivo methods for drug absorption–comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API …
E Sjögren, B Abrahamsson, P Augustijns… - European Journal of …, 2014 - Elsevier
This review summarizes the current knowledge on anatomy and physiology of the human
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …
The nutritional and pharmacological consequences of obesity surgery
J Stein, C Stier, H Raab… - Alimentary pharmacology & …, 2014 - Wiley Online Library
Background Obesity surgery is acknowledged as a highly effective therapy for morbidly
obese patients. Beneficial short‐term effects on common comorbidities are practically …
obese patients. Beneficial short‐term effects on common comorbidities are practically …
Herb-drug interactions and hepatotoxicity
MK Parvez, V Rishi - Current drug metabolism, 2019 - ingentaconnect.com
Background: In recent times, herbals or phytomedicines have become very popular due to
their global acceptance as a complementary and alternative remedy. While modern drugs …
their global acceptance as a complementary and alternative remedy. While modern drugs …
Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans
Due to the rapid turnover of the small intestinal epithelia, the rate at which enterocyte
renewal occurs plays an important role in determining the level of drug-metabolizing …
renewal occurs plays an important role in determining the level of drug-metabolizing …
Integrating the impact of lipophilicity on potency and pharmacokinetic parameters enables the use of diverse chemical space during small molecule drug optimization
RR Miller, M Madeira, HB Wood… - Journal of Medicinal …, 2020 - ACS Publications
Lipophilicity has a dominant effect on many parameters that determine unbound drug
exposure as well as drug potency. Despite this, analysis of a large body of drug data …
exposure as well as drug potency. Despite this, analysis of a large body of drug data …
Delivery of lipophilic bioactives: assembly, disassembly, and reassembly of lipid nanoparticles
The oral bioavailability of lipophilic bioactive molecules can be greatly increased by
encapsulating them within engineered lipid nanoparticles (ELNs), such as micelles …
encapsulating them within engineered lipid nanoparticles (ELNs), such as micelles …
Constituents, Pharmacokinetics, and Pharmacology of Gegen-Qinlian Decoction
JZ Lu, D Ye, BL Ma - Frontiers in pharmacology, 2021 - frontiersin.org
Gegen-Qinlian decoction (GQD) is a classic traditional Chinese medicine (TCM) formula. It is
composed of four TCMs, including Puerariae Lobatae Radix, Scutellariae Radix, Coptidis …
composed of four TCMs, including Puerariae Lobatae Radix, Scutellariae Radix, Coptidis …