Evolution of the human pathogenic lifestyle in fungi

A Rokas - Nature Microbiology, 2022 - nature.com
Fungal pathogens cause more than a billion human infections every year, resulting in more
than 1.6 million deaths annually. Understanding the natural history and evolutionary ecology …

Aspergillus fumigatus and aspergillosis: From basics to clinics

A Arastehfar, A Carvalho, J Houbraken… - Studies in …, 2021 - ingentaconnect.com
The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by
causing numerous invasive infections and a notable mortality in humans, especially in …

Aspergillus fumigatus pan-genome analysis identifies genetic variants associated with human infection

AE Barber, T Sae-Ong, K Kang, B Seelbinder, J Li… - Nature …, 2021 - nature.com
Aspergillus fumigatus is an environmental saprobe and opportunistic human fungal
pathogen. Despite an estimated annual occurrence of more than 300,000 cases of invasive …

Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of Virulence Across Aspergillus Species

JL Steenwyk, ME Mead, SL Knowles, HA Raja… - Genetics, 2020 - academic.oup.com
Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of
Virulence Across Aspergillus Species | Genetics | Oxford Academic Skip to Main Content …

Molecular diagnostics for invasive fungal diseases: Current and future approaches

D Pham, V Sivalingam, HM Tang, JM Montgomery… - Journal of Fungi, 2024 - mdpi.com
Invasive fungal diseases (IFDs) comprise a growing healthcare burden, especially given the
expanding population of immunocompromised hosts. Early diagnosis of IFDs is required to …

Invasive Aspergillosis and the Impact of Azole-resistance

D Bosetti, D Neofytos - Current Fungal Infection Reports, 2023 - Springer
Purpose of Review IA (invasive aspergillosis) caused by azole-resistant strains has been
associated with higher clinical burden and mortality rates. We review the current …

Pan-azole- and multi-fungicide-resistant Aspergillus fumigatus is widespread in the United States

BN Celia-Sanchez, B Mangum… - Applied and …, 2024 - journals.asm.org
Aspergillus fumigatus is an important global fungal pathogen of humans. Azole drugs are
among the most effective treatments for A. fumigatus infection. Azoles are also widely used …

Genomic and phenotypic analysis of COVID-19-associated pulmonary aspergillosis isolates of Aspergillus fumigatus

JL Steenwyk, ME Mead, PA de Castro… - Microbiology …, 2021 - Am Soc Microbiol
The ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), first described in …

Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response

EA Alpizar-Sosa, NRB Ithnin, W Wei… - PLoS Neglected …, 2022 - journals.plos.org
Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen
independent lines of Leishmania mexicana and one L. infantum line were selected for …

Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens

MÀ Schikora-Tamarit, T Gabaldón - Biochemical Society …, 2022 - portlandpress.com
Fungal pathogens pose an increasingly worrying threat to human health, food security and
ecosystem diversity. To tackle fungal infections and improve current diagnostic and …