Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Abstract Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

The blood brain barrier (BBB) plays a crucial role in maintaining brain homeostasis by
selectively preventing the entry of substances from the peripheral blood into the central …

Abstract The Keap1–Nrf2–ARE ((Kelch‐like ECH‐Associating protein 1) nuclear factor
erythroid 2 related factor 2‐antioxidant response element) pathway is one of the most …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

Diabetes is a disease that can be treated with oral antidiabetic agents and/or insulin.
However, patients' metabolic control is inadequate in a high percentage of them and a major …

The aging population worldwide is facing a significant increase in age-related non-
communicable diseases, including cardiovascular and brain pathologies. This …

Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …

Despite improvements in awareness and treatment of type II diabetes mellitus (TIIDM), this
disease remains a major source of morbidity and mortality worldwide, and prevalence …