The Fos protein complex and several Fos-related antigens (FRA) bind specifically to a
sequence element referred to as the HeLa cell activator protein 1 (AP-1) binding site. A …

The gonadotropin FSH plays a key role in the control of Sertoli cell function. The FSH
molecular mechanism of action is best recognized for its stimulation of the adenylyl …

Using positional cloning strategies, we have identified a CTG triplet repeat that undergoes
expansion in myotonic dystrophy patients. This sequence is highly variable in the normal …

This unit provides an overview of DNA microarrays. Microarrays are a technology in which
thousands of nucleic acids are bound to a surface and are used to measure the relative …

Mice carrying null mutations in the myogenic regulatory factors Myf-5 or YyoD have
apparently normal skeletal muscle. To address whether these two factors functionally …

We have generated transgenic mouse lines carrying and expressing wild‐type and 3′‐
modified human tumour necrosis factor (hTNF‐alpha, cachectin) transgenes. We show that …

THE mouse H19 gene encodes one of the most abundant RNAs in the develo** mouse
embryo1. It is expressed at the blastocyst stage of development, and accumulates to high …

Prostate cancer is the most commonly diagnosed malignancy and the second leading cause
of cancer-related deaths in the Western male population. Despite the tremendous efforts that …

PrPc is a host protein anchored to the outer surface of neurons and to a lesser extent of
lymphocytes and other cells. The transmissible agent (prion) responsible for scrapie is …

Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be
identified. We show here that cultured Drosophila cells transfected with a novel member of …