The aim of this ESC Guideline is to help health professionals manage people with heart
failure (HF) according to the best available evidence. Fortunately, we now have a wealth of …

Heart Failure (HF) is a multi-faceted and life-threatening syndrome characterized by
significant morbidity and mortality, poor functional capacity and quality of life, and high costs …

Abstract Document Reviewers: Rudolf A. de Boer (CPG Review Coordinator)(Netherlands),
P. Christian Schulze (CPG Review Coordinator)(Germany), Magdy Abdelhamid (Egypt) …

Cirrhosis is an important cause of morbidity and mortality in people with chronic liver
disease worldwide. In 2019, cirrhosis was associated with 2.4% of global deaths. Owing to …

Background Combating viral hepatitis is part of the UN Sustainable Development Goals
(SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector …

Diabetes mellitus is a leading cause of mortality and reduced life expectancy. We aim to
estimate the burden of diabetes by type, year, regions, and socioeconomic status in 195 …

Background Sepsis is life-threatening organ dysfunction due to a dysregulated host
response to infection. It is considered a major cause of health loss, but data for the global …

Background Health system planning requires careful assessment of chronic kidney disease
(CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non …

Background Accurate data on type 1 diabetes prevalence, incidence, associated mortality
and life expectancy are crucial to inform public health policy, but these data are scarce. We …

The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …