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Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
F Lyko - Nature Reviews Genetics, 2018 - nature.com
The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …
The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark
It is a well‐known fact that RNA is the target of a plethora of modifications which currently
amount to over a hundred. The vast majority of these modifications was observed in the two …
amount to over a hundred. The vast majority of these modifications was observed in the two …
Extreme genomic CpG deficiency in SARS-CoV-2 and evasion of host antiviral defense
Wild mammalian species, including bats, constitute the natural reservoir of betacoronavirus
(including SARS, MERS, and the deadly SARS-CoV-2). Different hosts or host tissues …
(including SARS, MERS, and the deadly SARS-CoV-2). Different hosts or host tissues …
The role of RNA m5C modification in cancer metastasis
Epigenetic modification plays a crucial regulatory role in the biological processes of
eukaryotic cells. The recent characterization of DNA and RNA methylation is still ongoing …
eukaryotic cells. The recent characterization of DNA and RNA methylation is still ongoing …
Eukaryotic cytosine methyltransferases
▪ Abstract Large-genome eukaryotes use heritable cytosine methylation to silence
promoters, especially those associated with transposons and imprinted genes. Cytosine …
promoters, especially those associated with transposons and imprinted genes. Cytosine …
Identification of direct targets and modified bases of RNA cytosine methyltransferases
The extent and biological impact of RNA cytosine methylation are poorly understood, in part
owing to limitations of current techniques for determining the targets of RNA …
owing to limitations of current techniques for determining the targets of RNA …
Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2
The sequence and the structure of DNA methyltransferase-2 (Dnmt2) bear close affinities to
authentic DNA cytosine methyltransferases. A combined genetic and biochemical approach …
authentic DNA cytosine methyltransferases. A combined genetic and biochemical approach …
Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases
DNA methyltransferases catalyze the transfer of a methyl group from S‐adenosyl‐l‐
methionine to cytosine or adenine bases in DNA. These enzymes challenge the …
methionine to cytosine or adenine bases in DNA. These enzymes challenge the …
SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold
The S-adenosylmethionine-dependent methyltransferase enzymes share little sequence
identity, but incorporate a highly conserved structural fold. Surprisingly, residues that bind …
identity, but incorporate a highly conserved structural fold. Surprisingly, residues that bind …